Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy

P. Bhanumathi, P. Uma Devi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.

Original languageEnglish
Pages (from-to)562-564
Number of pages3
JournalIndian Journal of Experimental Biology
Volume32
Issue number8
Publication statusPublished - 01-01-1994
Externally publishedYes

Fingerprint

Tiopronin
Cyclophosphamide
Lipid Peroxidation
Glutathione
Drug Therapy
Liver
Therapeutics
WR 77913

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

Cite this

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title = "Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy",
abstract = "Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.",
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Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy. / Bhanumathi, P.; Uma Devi, P.

In: Indian Journal of Experimental Biology, Vol. 32, No. 8, 01.01.1994, p. 562-564.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy

AU - Bhanumathi, P.

AU - Uma Devi, P.

PY - 1994/1/1

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N2 - Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.

AB - Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.

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