Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.
|Number of pages||3|
|Journal||Indian Journal of Experimental Biology|
|Publication status||Published - 01-01-1994|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology