Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy

P. Bhanumathi; P. Uma Devi

Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy

P. Bhanumathi, P. Uma Devi

Research output: Contribution to journal › Article › peer-review

Abstract

Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.

Original language	English
Pages (from-to)	562-564
Number of pages	3
Journal	Indian Journal of Experimental Biology
Volume	32
Issue number	8
Publication status	Published - 01-01-1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Medicine(all)
Molecular Biology
Cell Biology

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title = "Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy",

abstract = "Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.",

author = "P. Bhanumathi and {Uma Devi}, P.",

year = "1994",

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AU - Uma Devi, P.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.

AB - Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.

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ER -

Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy

Abstract

All Science Journal Classification (ASJC) codes

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