Abstract
Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 562-564 |
| Number of pages | 3 |
| Journal | Indian Journal of Experimental Biology |
| Volume | 32 |
| Issue number | 8 |
| Publication status | Published - 01-01-1994 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Medicine(all)
- Molecular Biology
- Cell Biology
Cite this
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Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy. / Bhanumathi, P.; Uma Devi, P.
In: Indian Journal of Experimental Biology, Vol. 32, No. 8, 01.01.1994, p. 562-564.Research output: Contribution to journal › Article
TY - JOUR
T1 - Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy
AU - Bhanumathi, P.
AU - Uma Devi, P.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.
AB - Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.
UR - http://www.scopus.com/inward/record.url?scp=0028037693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028037693&partnerID=8YFLogxK
M3 - Article
VL - 32
SP - 562
EP - 564
JO - Journal of scientific & industrial research. C. Biological sciences
JF - Journal of scientific & industrial research. C. Biological sciences
SN - 0019-5189
IS - 8
ER -