Abstract
Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MRC or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 562-564 |
| Number of pages | 3 |
| Journal | Indian Journal of Experimental Biology |
| Volume | 32 |
| Issue number | 8 |
| Publication status | Published - 01-01-1994 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biotechnology
- Medicine(all)
- Molecular Biology
- Cell Biology
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Bhanumathi, P., & Uma Devi, P. (1994). Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionylglycine in cyclophosphamide chemotherapy. Indian Journal of Experimental Biology, 32(8), 562-564.