TY - JOUR
T1 - Modulation of gut microbiota
T2 - An emerging consequence in neonatal sepsis
AU - Iqbal, Faiza
AU - Lewis, Leslie Edward S.
AU - Siva, N.
AU - K E, Vandana
AU - Purkayastha, Jayashree
AU - Shenoy, Padmaja A.
N1 - Funding Information:
The authors would like to acknowledge Kasturba Medical College and Manipal Academy of Higher Education for providing technical support.
Publisher Copyright:
© 2023
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Introduction: Billions of microorganisms reside in gut altering its homeostasis and leading to various diseases. The initial days of life are crucial for developing gut flora that helps in gut maturation and neonatal health. This review summarizes the evidence on seeding of neonatal gut microbiota, modulation of gut microbiota in neonatal sepsis, antimicrobial resistance, and role of probiotics or other therapies to re-establish altered microbiota. Conclusion: Gut microbiota regulates host physiological homeostasis mediators, including the gut barrier function, and disease susceptibility pathways. Maintenance or restoration of microbiota and metabolite composition may be a therapeutic or preventative target against critical illness.
AB - Introduction: Billions of microorganisms reside in gut altering its homeostasis and leading to various diseases. The initial days of life are crucial for developing gut flora that helps in gut maturation and neonatal health. This review summarizes the evidence on seeding of neonatal gut microbiota, modulation of gut microbiota in neonatal sepsis, antimicrobial resistance, and role of probiotics or other therapies to re-establish altered microbiota. Conclusion: Gut microbiota regulates host physiological homeostasis mediators, including the gut barrier function, and disease susceptibility pathways. Maintenance or restoration of microbiota and metabolite composition may be a therapeutic or preventative target against critical illness.
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U2 - 10.1016/j.cegh.2023.101245
DO - 10.1016/j.cegh.2023.101245
M3 - Review article
AN - SCOPUS:85147353526
SN - 2213-3984
VL - 20
JO - Clinical Epidemiology and Global Health
JF - Clinical Epidemiology and Global Health
M1 - 101245
ER -
