Modulation of mitoxantrone cytotoxicity by verapamil in human chronic myeloid leukemia cells

K. Satyamoorthy, M. P. Chitnis, S. G. Pradhan, S. H. Advani

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Calcium channel-blocking agent verapamil has been established to bean effective drug to modulate the action of many anticancer drugs. In this study, we examined the effect of verapamil on the cytotoxicity of mitoxantrone in human chronic myeloid leukemia (CML) cells. Mitoxantrone alone exhibited dose-dependent inhibition of DNA biosynthesis in CML cells. The addition of verapamil (3.3 μM) enhanced the responsiveness of CML cells to mitoxantrone (I μg/ml) cytotoxicity indicated by significant increased inhibition of thymidine incorporation (p < 0.001). The present study demonstrates the possible efficacy of verapamil in the chemotherapy of CML with mitoxantrone.

    Original languageEnglish
    Pages (from-to)128-131
    Number of pages4
    JournalOncology (Switzerland)
    Volume46
    Issue number2
    DOIs
    Publication statusPublished - 1989

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    All Science Journal Classification (ASJC) codes

    • Oncology
    • Cancer Research

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