Modulation of radiation-induced alteration in the antioxidant status of mice by naringin

Ganesh Chandra Jagetia, Tiyyagura Koti Reddy

Research output: Contribution to journalArticlepeer-review

139 Citations (Scopus)

Abstract

The alteration in the antioxidant status and lipid peroxidation was investigated in Swiss albino mice treated with 2 mg/kg b.wt. naringin, a citrus flavoglycoside, before exposure to 0.5, 1, 2, 3, and 4 Gy gamma radiation. Lipid peroxidation, glutathione, glutathione peroxidase, catalase and superoxide dismutase were determined in the liver and small intestine of mice treated or not with naringin at 0.5, 1, 2, 4 and 8 h post-irradiation. Whole-body irradiation of mice caused a dose dependent elevation in the lipid peroxidation while a dose dependent depletion was observed for glutathione, glutathione peroxidase, superoxide dismutase and catalase in both liver as well as small intestine. Treatment of mice with 2 mg/kg b. wt. naringin inhibited the radiation-induced elevation in the lipid peroxidation as well as depletion of glutathione, glutathione peroxidase, superoxide dismutase and catalase in liver and small intestine. Radiation-induced lipid peroxidation increased with time, which was greatest at 2 h post-irradiation and declined therafter in the liver and small intestine. Similarly, a maximum decline in the glutathione glutathione peroxidase, and superoxide dismutase was observed at 1 h, while catalase showed a maximum decline at 2 h post-irradation. Our study demonstrates that naringin protects mouse liver and intestine against the radiation-induced damage by elevating the antioxidant status and reducing the lipid peroxidation.

Original languageEnglish
Pages (from-to)780-794
Number of pages15
JournalLife Sciences
Volume77
Issue number7
DOIs
Publication statusPublished - 01-07-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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