Modulation of sensitivity to mitoxantrone in human chronic myeloid leukemia cells by the antidepressant sintamil

M. P. Chitnis, K. Satyamoorthy, S. G. Pradhan, S. H. Advani

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    The utility of mitoxantrone (MTN) in the cytotoxic chemotherapy of human chronic myeloid leukemia (CML) is envisaged. In the present study we employed marginally toxic concentration of MTN and the antidepressant sintamil (SNT) as drug response modulator to evaluate the heterogenous response to chemotherapy by CML cells and to potentiate the cytotoxicity of MTN. In vitro results from 26 different CML blood samples displayed variation in cytotoxicity of MTN (1 μg/ml) alone and in the resulting synergistic inhibition of DNA biosynthesis with the combination of SNT (10 μg/ml). Of the 26 samples studied, 14 samples indicated synergistic, 2 additive, and 11 less than additive cytotoxic effects due to the combined treatment with MTN and SNT. The cytotoxicity induced by MTN alone and the combination with SNT was found to be irreversible. Data suggest the utility of MTN alone and in combination with SNT in the treatment of CML and warrant further studies for the evaluation in the clinics.

    Original languageEnglish
    Pages (from-to)292-296
    Number of pages5
    JournalOncology
    Volume45
    Issue number4
    Publication statusPublished - 1988

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    Mitoxantrone
    Myeloid Cells
    Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    Antidepressive Agents
    Drug Therapy
    Poisons
    sintamil
    DNA
    Therapeutics
    Pharmaceutical Preparations

    All Science Journal Classification (ASJC) codes

    • Cancer Research
    • Oncology

    Cite this

    Chitnis, M. P. ; Satyamoorthy, K. ; Pradhan, S. G. ; Advani, S. H. / Modulation of sensitivity to mitoxantrone in human chronic myeloid leukemia cells by the antidepressant sintamil. In: Oncology. 1988 ; Vol. 45, No. 4. pp. 292-296.
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    Modulation of sensitivity to mitoxantrone in human chronic myeloid leukemia cells by the antidepressant sintamil. / Chitnis, M. P.; Satyamoorthy, K.; Pradhan, S. G.; Advani, S. H.

    In: Oncology, Vol. 45, No. 4, 1988, p. 292-296.

    Research output: Contribution to journalArticle

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    AU - Chitnis, M. P.

    AU - Satyamoorthy, K.

    AU - Pradhan, S. G.

    AU - Advani, S. H.

    PY - 1988

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    N2 - The utility of mitoxantrone (MTN) in the cytotoxic chemotherapy of human chronic myeloid leukemia (CML) is envisaged. In the present study we employed marginally toxic concentration of MTN and the antidepressant sintamil (SNT) as drug response modulator to evaluate the heterogenous response to chemotherapy by CML cells and to potentiate the cytotoxicity of MTN. In vitro results from 26 different CML blood samples displayed variation in cytotoxicity of MTN (1 μg/ml) alone and in the resulting synergistic inhibition of DNA biosynthesis with the combination of SNT (10 μg/ml). Of the 26 samples studied, 14 samples indicated synergistic, 2 additive, and 11 less than additive cytotoxic effects due to the combined treatment with MTN and SNT. The cytotoxicity induced by MTN alone and the combination with SNT was found to be irreversible. Data suggest the utility of MTN alone and in combination with SNT in the treatment of CML and warrant further studies for the evaluation in the clinics.

    AB - The utility of mitoxantrone (MTN) in the cytotoxic chemotherapy of human chronic myeloid leukemia (CML) is envisaged. In the present study we employed marginally toxic concentration of MTN and the antidepressant sintamil (SNT) as drug response modulator to evaluate the heterogenous response to chemotherapy by CML cells and to potentiate the cytotoxicity of MTN. In vitro results from 26 different CML blood samples displayed variation in cytotoxicity of MTN (1 μg/ml) alone and in the resulting synergistic inhibition of DNA biosynthesis with the combination of SNT (10 μg/ml). Of the 26 samples studied, 14 samples indicated synergistic, 2 additive, and 11 less than additive cytotoxic effects due to the combined treatment with MTN and SNT. The cytotoxicity induced by MTN alone and the combination with SNT was found to be irreversible. Data suggest the utility of MTN alone and in combination with SNT in the treatment of CML and warrant further studies for the evaluation in the clinics.

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