Modulatory effect of vitamin C on genotoxic effect of endosulfan in developing albino rats

Shimoga Durgojirao Manjula, Susan Benjamin, Kurady Laxminarayana Bairy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12 mg/kg Endosulfan orally (10 pups/group), for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9 mg/kg and 12 mg/kg was administered along with vitamin C (20 mg/kg). One more group of rats were treated with cyclophosphamide as positive control. The genotoxic effect was studied by bone marrow micronuclei assay. There was an increase in micronuclei in polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) and a decrease in PCE and P/N ratio in endosulfan treated rats. The effect was similar to the standard mutagen cyclophosphamide. In rats treated with vitamin C and endosulfan, there was an increase in PCE and P/N ratio and decrease in micronuclei in PCE and NCE. This could be due to the antimutagenic effect of vitamin C.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalIranian Journal of Pharmacology and Therapeutics
Volume5
Issue number2
Publication statusPublished - 01-12-2006

Fingerprint

Endosulfan
Ascorbic Acid
Erythrocytes
Micronucleus Tests
Cyclophosphamide
Bone Marrow
Antimutagenic Agents
Mutagens
Wistar Rats

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Manjula, Shimoga Durgojirao ; Benjamin, Susan ; Bairy, Kurady Laxminarayana. / Modulatory effect of vitamin C on genotoxic effect of endosulfan in developing albino rats. In: Iranian Journal of Pharmacology and Therapeutics. 2006 ; Vol. 5, No. 2. pp. 113-116.
@article{84109b55c04e4e9684e70e7c5bb06407,
title = "Modulatory effect of vitamin C on genotoxic effect of endosulfan in developing albino rats",
abstract = "The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12 mg/kg Endosulfan orally (10 pups/group), for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9 mg/kg and 12 mg/kg was administered along with vitamin C (20 mg/kg). One more group of rats were treated with cyclophosphamide as positive control. The genotoxic effect was studied by bone marrow micronuclei assay. There was an increase in micronuclei in polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) and a decrease in PCE and P/N ratio in endosulfan treated rats. The effect was similar to the standard mutagen cyclophosphamide. In rats treated with vitamin C and endosulfan, there was an increase in PCE and P/N ratio and decrease in micronuclei in PCE and NCE. This could be due to the antimutagenic effect of vitamin C.",
author = "Manjula, {Shimoga Durgojirao} and Susan Benjamin and Bairy, {Kurady Laxminarayana}",
year = "2006",
month = "12",
day = "1",
language = "English",
volume = "5",
pages = "113--116",
journal = "Iranian Journal of Pharmacology and Therapeutics",
issn = "1735-2657",
publisher = "Academy of Medical Sciences of I.R. Iran",
number = "2",

}

Modulatory effect of vitamin C on genotoxic effect of endosulfan in developing albino rats. / Manjula, Shimoga Durgojirao; Benjamin, Susan; Bairy, Kurady Laxminarayana.

In: Iranian Journal of Pharmacology and Therapeutics, Vol. 5, No. 2, 01.12.2006, p. 113-116.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Modulatory effect of vitamin C on genotoxic effect of endosulfan in developing albino rats

AU - Manjula, Shimoga Durgojirao

AU - Benjamin, Susan

AU - Bairy, Kurady Laxminarayana

PY - 2006/12/1

Y1 - 2006/12/1

N2 - The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12 mg/kg Endosulfan orally (10 pups/group), for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9 mg/kg and 12 mg/kg was administered along with vitamin C (20 mg/kg). One more group of rats were treated with cyclophosphamide as positive control. The genotoxic effect was studied by bone marrow micronuclei assay. There was an increase in micronuclei in polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) and a decrease in PCE and P/N ratio in endosulfan treated rats. The effect was similar to the standard mutagen cyclophosphamide. In rats treated with vitamin C and endosulfan, there was an increase in PCE and P/N ratio and decrease in micronuclei in PCE and NCE. This could be due to the antimutagenic effect of vitamin C.

AB - The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12 mg/kg Endosulfan orally (10 pups/group), for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9 mg/kg and 12 mg/kg was administered along with vitamin C (20 mg/kg). One more group of rats were treated with cyclophosphamide as positive control. The genotoxic effect was studied by bone marrow micronuclei assay. There was an increase in micronuclei in polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) and a decrease in PCE and P/N ratio in endosulfan treated rats. The effect was similar to the standard mutagen cyclophosphamide. In rats treated with vitamin C and endosulfan, there was an increase in PCE and P/N ratio and decrease in micronuclei in PCE and NCE. This could be due to the antimutagenic effect of vitamin C.

UR - http://www.scopus.com/inward/record.url?scp=40149096034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40149096034&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 113

EP - 116

JO - Iranian Journal of Pharmacology and Therapeutics

JF - Iranian Journal of Pharmacology and Therapeutics

SN - 1735-2657

IS - 2

ER -