Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats

Phani Krishna Kondamudi, Hemalatha Kovelamudi, Geetha Mathew, Pawan G. Nayak, C. Mallikarjuna Rao, Rekha R. Shenoy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal tract of immune, genetic and environmental origin. In the present study, we examined the effect of sesamol (SES), the main anti-oxidative constituent of Sesamum indicum (sesame seed) Linn. in the dinitrochlorobenzene (DNCB)-induced model for IBD in rats. Methods: The groups were divided into normal control, DNCB control, SES and sulfasalazine (SS). On day 24, the rats were killed, colon removed and the macroscopic, biochemical and histopathological evaluations were performed. Results: The levels of MPO, TBARS and nitrite increased significantly (p < 0.05) in the DNCB group, whereas reduced significantly in the SES, SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. IL-6 and TNF-α levels were significantly high in the DNCB group. Conclusions:We conclude the mucosal protective effect of SESon colon due to its potent antioxidant actions. Further investigation is required in a chronic model of different rodent strain for its role involved in the cytokine pathway.

Original languageEnglish
Pages (from-to)658-665
Number of pages8
JournalPharmacological Reports
Volume65
Issue number3
DOIs
Publication statusPublished - 2013

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Dinitrochlorobenzene
Sesamum
Sulfasalazine
Nitrites
Inflammatory Bowel Diseases
Colon
Gastrointestinal Tract
Rodentia
Interleukin-6
Seeds
Antioxidants
Cytokines
sesamol
Serum

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Kondamudi, Phani Krishna ; Kovelamudi, Hemalatha ; Mathew, Geetha ; Nayak, Pawan G. ; Mallikarjuna Rao, C. ; Shenoy, Rekha R. / Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats. In: Pharmacological Reports. 2013 ; Vol. 65, No. 3. pp. 658-665.
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Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats. / Kondamudi, Phani Krishna; Kovelamudi, Hemalatha; Mathew, Geetha; Nayak, Pawan G.; Mallikarjuna Rao, C.; Shenoy, Rekha R.

In: Pharmacological Reports, Vol. 65, No. 3, 2013, p. 658-665.

Research output: Contribution to journalArticle

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AU - Mallikarjuna Rao, C.

AU - Shenoy, Rekha R.

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N2 - Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal tract of immune, genetic and environmental origin. In the present study, we examined the effect of sesamol (SES), the main anti-oxidative constituent of Sesamum indicum (sesame seed) Linn. in the dinitrochlorobenzene (DNCB)-induced model for IBD in rats. Methods: The groups were divided into normal control, DNCB control, SES and sulfasalazine (SS). On day 24, the rats were killed, colon removed and the macroscopic, biochemical and histopathological evaluations were performed. Results: The levels of MPO, TBARS and nitrite increased significantly (p < 0.05) in the DNCB group, whereas reduced significantly in the SES, SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. IL-6 and TNF-α levels were significantly high in the DNCB group. Conclusions:We conclude the mucosal protective effect of SESon colon due to its potent antioxidant actions. Further investigation is required in a chronic model of different rodent strain for its role involved in the cytokine pathway.

AB - Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal tract of immune, genetic and environmental origin. In the present study, we examined the effect of sesamol (SES), the main anti-oxidative constituent of Sesamum indicum (sesame seed) Linn. in the dinitrochlorobenzene (DNCB)-induced model for IBD in rats. Methods: The groups were divided into normal control, DNCB control, SES and sulfasalazine (SS). On day 24, the rats were killed, colon removed and the macroscopic, biochemical and histopathological evaluations were performed. Results: The levels of MPO, TBARS and nitrite increased significantly (p < 0.05) in the DNCB group, whereas reduced significantly in the SES, SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. IL-6 and TNF-α levels were significantly high in the DNCB group. Conclusions:We conclude the mucosal protective effect of SESon colon due to its potent antioxidant actions. Further investigation is required in a chronic model of different rodent strain for its role involved in the cytokine pathway.

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