Molecular implications of HOX genes targeting multiple signaling pathways in cancer

U. Sangeetha Shenoy, Divya Adiga, Shama Prasada Kabekkodu, Keith D. Hunter, Raghu Radhakrishnan

Research output: Contribution to journalReview articlepeer-review

Abstract

Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
JournalCell Biology and Toxicology
DOIs
Publication statusAccepted/In press - 2021

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Cell Biology
  • Health, Toxicology and Mutagenesis

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