Morphometric Analysis of Nuclear Features and Volume-Corrected Mitotic Index in the Prognosis of Oral Squamous Cell Carcinoma

Srikant Natarajan, Sumita Mahajan, Karen Boaz, Thomas George

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In the present study, an objective and reproducible evaluation of mitotic activity and nuclear morphometric factors was attempted in 30 patients of oral squamous cell carcinoma with a view to predicting local relapse and survival. Various nuclear parameters and volume-corrected mitotic index were calculated and compared with the recurrence and death of the study group (n = 30). Volume-corrected mitotic index (M/V index) was the single best prognosticator for recurrence of oral squamous cell carcinoma (p = 0.008 for recurrence; p = 0.015 for death). The combination of M/V and SD of nuclear area (forward stepwise regression) was a more efficient and better predictor of survival (Log rank test, Kaplan-Meier's survival analysis; X2 = 17.46, p = 0.00001). The present study proved the effectiveness of the M/V index in predicting the biological behavior and the outcome of oral squamous cell carcinoma patients.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalOral Science International
Volume6
Issue number2
DOIs
Publication statusPublished - 01-01-2009

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Mitotic Index
Squamous Cell Carcinoma
Recurrence
Survival
Kaplan-Meier Estimate
Survival Analysis

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

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Morphometric Analysis of Nuclear Features and Volume-Corrected Mitotic Index in the Prognosis of Oral Squamous Cell Carcinoma. / Natarajan, Srikant; Mahajan, Sumita; Boaz, Karen; George, Thomas.

In: Oral Science International, Vol. 6, No. 2, 01.01.2009, p. 85-94.

Research output: Contribution to journalArticle

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