Abstract

Objective: Chemotherapy causes destruction of neoplastic cells and rapidly proliferative normal cells leading to significant mucocutaneous changes. The aim of the present study was to determine the postchemotherapeutic mucocutaneous manifestations in pediatric malignancies. Methods: In this cross-sectional study, 63 children with malignancy undergoing chemotherapy over 2½ years were examined carefully and followed up for 6 months. A comprehensive clinical history was taken. Detailed systemic and dermatological examination was carried out in the subjects at the time of enrollment. Dermatological examination was performed subsequently at 3-6 months and whenever child presented with any symptoms to the outpatient department. The chemotherapy-induced alopecia (CIA) and pigmentary changes of skin and nails were graded using OSLEN CIA, National Cancer Institute pigment changes and nail changes’ grading scales. Results: Males (41 [65%]) outnumbered females (1.8:1). Acute lymphoblastic and myelogenous leukemia were noticed in 38 (60.3%) and 8 (12.6%) patients, respectively. Alopecia (43 [68.3%]) was common with predominant grade 3 (22 [34.92%]). Hair regrowth was noticed in 53 (83.7%) patients within 6 months. Cutaneous linear pigmentary lines, ichthyosis, acral pigmentation, skin peeling, and mucositis were observed in 13 (21%), 10 (16%), 10 (16%), 7 (11%), and 9 (14.28%) patients, respectively. Among 56 infections included, viral-4 cases of herpes zoster, single case of extensive molluscum and varicella. Tinea faciei was recurrent and poorly responsive to treatment. The common nail changes noted were Muehrcke’s lines and melanonychia (26 [41.26%]). Conclusion: Alopecia in 43 (68.3%) patients though distressing was reversible in 53 (83.7%) patients. Infections were extensive, recurrent, and required aggressive treatment.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume9
Issue number4
Publication statusPublished - 01-07-2016

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Alopecia
Pediatrics
Drug Therapy
Nails
Neoplasms
Skin Pigmentation
Ichthyosis
Skin
Tinea
Mucositis
Chickenpox
National Cancer Institute (U.S.)
Mollusca
Herpes Zoster
Virus Diseases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Hair
Outpatients
Extremities

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

@article{3c7e1d3b3d264289a1e5ba5d10c13ee0,
title = "Mucocutaneous manifestations following chemotherapy in pediatric malignancies",
abstract = "Objective: Chemotherapy causes destruction of neoplastic cells and rapidly proliferative normal cells leading to significant mucocutaneous changes. The aim of the present study was to determine the postchemotherapeutic mucocutaneous manifestations in pediatric malignancies. Methods: In this cross-sectional study, 63 children with malignancy undergoing chemotherapy over 2½ years were examined carefully and followed up for 6 months. A comprehensive clinical history was taken. Detailed systemic and dermatological examination was carried out in the subjects at the time of enrollment. Dermatological examination was performed subsequently at 3-6 months and whenever child presented with any symptoms to the outpatient department. The chemotherapy-induced alopecia (CIA) and pigmentary changes of skin and nails were graded using OSLEN CIA, National Cancer Institute pigment changes and nail changes’ grading scales. Results: Males (41 [65{\%}]) outnumbered females (1.8:1). Acute lymphoblastic and myelogenous leukemia were noticed in 38 (60.3{\%}) and 8 (12.6{\%}) patients, respectively. Alopecia (43 [68.3{\%}]) was common with predominant grade 3 (22 [34.92{\%}]). Hair regrowth was noticed in 53 (83.7{\%}) patients within 6 months. Cutaneous linear pigmentary lines, ichthyosis, acral pigmentation, skin peeling, and mucositis were observed in 13 (21{\%}), 10 (16{\%}), 10 (16{\%}), 7 (11{\%}), and 9 (14.28{\%}) patients, respectively. Among 56 infections included, viral-4 cases of herpes zoster, single case of extensive molluscum and varicella. Tinea faciei was recurrent and poorly responsive to treatment. The common nail changes noted were Muehrcke’s lines and melanonychia (26 [41.26{\%}]). Conclusion: Alopecia in 43 (68.3{\%}) patients though distressing was reversible in 53 (83.7{\%}) patients. Infections were extensive, recurrent, and required aggressive treatment.",
author = "Sudarshan Rajashekar and Maria Kuruvila and Kamalakshi Bhat and Unnikrishnan Bhaskaran",
year = "2016",
month = "7",
day = "1",
language = "English",
volume = "9",
pages = "161--164",
journal = "Asian Journal of Pharmaceutical and Clinical Research",
issn = "0974-2441",
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TY - JOUR

T1 - Mucocutaneous manifestations following chemotherapy in pediatric malignancies

AU - Rajashekar, Sudarshan

AU - Kuruvila, Maria

AU - Bhat, Kamalakshi

AU - Bhaskaran, Unnikrishnan

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Objective: Chemotherapy causes destruction of neoplastic cells and rapidly proliferative normal cells leading to significant mucocutaneous changes. The aim of the present study was to determine the postchemotherapeutic mucocutaneous manifestations in pediatric malignancies. Methods: In this cross-sectional study, 63 children with malignancy undergoing chemotherapy over 2½ years were examined carefully and followed up for 6 months. A comprehensive clinical history was taken. Detailed systemic and dermatological examination was carried out in the subjects at the time of enrollment. Dermatological examination was performed subsequently at 3-6 months and whenever child presented with any symptoms to the outpatient department. The chemotherapy-induced alopecia (CIA) and pigmentary changes of skin and nails were graded using OSLEN CIA, National Cancer Institute pigment changes and nail changes’ grading scales. Results: Males (41 [65%]) outnumbered females (1.8:1). Acute lymphoblastic and myelogenous leukemia were noticed in 38 (60.3%) and 8 (12.6%) patients, respectively. Alopecia (43 [68.3%]) was common with predominant grade 3 (22 [34.92%]). Hair regrowth was noticed in 53 (83.7%) patients within 6 months. Cutaneous linear pigmentary lines, ichthyosis, acral pigmentation, skin peeling, and mucositis were observed in 13 (21%), 10 (16%), 10 (16%), 7 (11%), and 9 (14.28%) patients, respectively. Among 56 infections included, viral-4 cases of herpes zoster, single case of extensive molluscum and varicella. Tinea faciei was recurrent and poorly responsive to treatment. The common nail changes noted were Muehrcke’s lines and melanonychia (26 [41.26%]). Conclusion: Alopecia in 43 (68.3%) patients though distressing was reversible in 53 (83.7%) patients. Infections were extensive, recurrent, and required aggressive treatment.

AB - Objective: Chemotherapy causes destruction of neoplastic cells and rapidly proliferative normal cells leading to significant mucocutaneous changes. The aim of the present study was to determine the postchemotherapeutic mucocutaneous manifestations in pediatric malignancies. Methods: In this cross-sectional study, 63 children with malignancy undergoing chemotherapy over 2½ years were examined carefully and followed up for 6 months. A comprehensive clinical history was taken. Detailed systemic and dermatological examination was carried out in the subjects at the time of enrollment. Dermatological examination was performed subsequently at 3-6 months and whenever child presented with any symptoms to the outpatient department. The chemotherapy-induced alopecia (CIA) and pigmentary changes of skin and nails were graded using OSLEN CIA, National Cancer Institute pigment changes and nail changes’ grading scales. Results: Males (41 [65%]) outnumbered females (1.8:1). Acute lymphoblastic and myelogenous leukemia were noticed in 38 (60.3%) and 8 (12.6%) patients, respectively. Alopecia (43 [68.3%]) was common with predominant grade 3 (22 [34.92%]). Hair regrowth was noticed in 53 (83.7%) patients within 6 months. Cutaneous linear pigmentary lines, ichthyosis, acral pigmentation, skin peeling, and mucositis were observed in 13 (21%), 10 (16%), 10 (16%), 7 (11%), and 9 (14.28%) patients, respectively. Among 56 infections included, viral-4 cases of herpes zoster, single case of extensive molluscum and varicella. Tinea faciei was recurrent and poorly responsive to treatment. The common nail changes noted were Muehrcke’s lines and melanonychia (26 [41.26%]). Conclusion: Alopecia in 43 (68.3%) patients though distressing was reversible in 53 (83.7%) patients. Infections were extensive, recurrent, and required aggressive treatment.

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M3 - Article

VL - 9

SP - 161

EP - 164

JO - Asian Journal of Pharmaceutical and Clinical Research

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