Mucoepidermoid carcinoma of salivary gland

Limitations and pitfalls on FNA

Geetha Vasudevan, Arijit Bishnu, Brij Mohan Kumar Singh, Varun Kumar Singh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Mucoepidermoid Carcinoma (MEC) is the most common malignant neoplasm of salivary gland origin. However, its morphologic heterogeneity poses difficulty in interpretation. In the present series we discuss the morphologic features of MEC, limitations and pitfalls in its diagnosis on Fine Needle Aspiration Cytology (FNAC). Fourteen cases of suspected MEC were evaluated cytologically followed by histopathological examination for confirmation. A definite cytological diagnosis was rendered in nine cases; three of the remaining five were underdiagnosed as abscess, pleomorphic adenoma and mucus cyst. Of the remaining two cases, one case each of sebaceous carcinoma and sialadenitis was mislabeled as MEC on cytology. A satisfactory aspirate composed of intermediate cells, mucin secreting cells and squamous cells in a mucinous background may not be obtained in all cases of low grade MEC. High grade MEC can be classified as squamous cell carcinoma. Hence, awareness of confounding factors with clinicopathologic correlation and judicious use of frozen section can help in minimizing errors.

Original languageEnglish
Pages (from-to)ER04-ER06
JournalJournal of Clinical and Diagnostic Research
Volume11
Issue number5
DOIs
Publication statusPublished - 01-05-2017
Externally publishedYes

Fingerprint

Cytology
Mucoepidermoid Carcinoma
Salivary Glands
Mucins
Needles
Cell Biology
Salivary Gland Neoplasms
Sialadenitis
Pleomorphic Adenoma
Frozen Sections
Mucus
Fine Needle Biopsy
Abscess
Epithelial Cells
Cysts
Squamous Cell Carcinoma
Carcinoma

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Vasudevan, Geetha ; Bishnu, Arijit ; Singh, Brij Mohan Kumar ; Singh, Varun Kumar. / Mucoepidermoid carcinoma of salivary gland : Limitations and pitfalls on FNA. In: Journal of Clinical and Diagnostic Research. 2017 ; Vol. 11, No. 5. pp. ER04-ER06.
@article{d95444df60114081af31e5ed5870d3e2,
title = "Mucoepidermoid carcinoma of salivary gland: Limitations and pitfalls on FNA",
abstract = "Mucoepidermoid Carcinoma (MEC) is the most common malignant neoplasm of salivary gland origin. However, its morphologic heterogeneity poses difficulty in interpretation. In the present series we discuss the morphologic features of MEC, limitations and pitfalls in its diagnosis on Fine Needle Aspiration Cytology (FNAC). Fourteen cases of suspected MEC were evaluated cytologically followed by histopathological examination for confirmation. A definite cytological diagnosis was rendered in nine cases; three of the remaining five were underdiagnosed as abscess, pleomorphic adenoma and mucus cyst. Of the remaining two cases, one case each of sebaceous carcinoma and sialadenitis was mislabeled as MEC on cytology. A satisfactory aspirate composed of intermediate cells, mucin secreting cells and squamous cells in a mucinous background may not be obtained in all cases of low grade MEC. High grade MEC can be classified as squamous cell carcinoma. Hence, awareness of confounding factors with clinicopathologic correlation and judicious use of frozen section can help in minimizing errors.",
author = "Geetha Vasudevan and Arijit Bishnu and Singh, {Brij Mohan Kumar} and Singh, {Varun Kumar}",
year = "2017",
month = "5",
day = "1",
doi = "10.7860/JCDR/2017/25341.9941",
language = "English",
volume = "11",
pages = "ER04--ER06",
journal = "Journal of Clinical and Diagnostic Research",
issn = "2249-782X",
publisher = "Journal of Clinical and Diagnostic Research",
number = "5",

}

Mucoepidermoid carcinoma of salivary gland : Limitations and pitfalls on FNA. / Vasudevan, Geetha; Bishnu, Arijit; Singh, Brij Mohan Kumar; Singh, Varun Kumar.

In: Journal of Clinical and Diagnostic Research, Vol. 11, No. 5, 01.05.2017, p. ER04-ER06.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mucoepidermoid carcinoma of salivary gland

T2 - Limitations and pitfalls on FNA

AU - Vasudevan, Geetha

AU - Bishnu, Arijit

AU - Singh, Brij Mohan Kumar

AU - Singh, Varun Kumar

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Mucoepidermoid Carcinoma (MEC) is the most common malignant neoplasm of salivary gland origin. However, its morphologic heterogeneity poses difficulty in interpretation. In the present series we discuss the morphologic features of MEC, limitations and pitfalls in its diagnosis on Fine Needle Aspiration Cytology (FNAC). Fourteen cases of suspected MEC were evaluated cytologically followed by histopathological examination for confirmation. A definite cytological diagnosis was rendered in nine cases; three of the remaining five were underdiagnosed as abscess, pleomorphic adenoma and mucus cyst. Of the remaining two cases, one case each of sebaceous carcinoma and sialadenitis was mislabeled as MEC on cytology. A satisfactory aspirate composed of intermediate cells, mucin secreting cells and squamous cells in a mucinous background may not be obtained in all cases of low grade MEC. High grade MEC can be classified as squamous cell carcinoma. Hence, awareness of confounding factors with clinicopathologic correlation and judicious use of frozen section can help in minimizing errors.

AB - Mucoepidermoid Carcinoma (MEC) is the most common malignant neoplasm of salivary gland origin. However, its morphologic heterogeneity poses difficulty in interpretation. In the present series we discuss the morphologic features of MEC, limitations and pitfalls in its diagnosis on Fine Needle Aspiration Cytology (FNAC). Fourteen cases of suspected MEC were evaluated cytologically followed by histopathological examination for confirmation. A definite cytological diagnosis was rendered in nine cases; three of the remaining five were underdiagnosed as abscess, pleomorphic adenoma and mucus cyst. Of the remaining two cases, one case each of sebaceous carcinoma and sialadenitis was mislabeled as MEC on cytology. A satisfactory aspirate composed of intermediate cells, mucin secreting cells and squamous cells in a mucinous background may not be obtained in all cases of low grade MEC. High grade MEC can be classified as squamous cell carcinoma. Hence, awareness of confounding factors with clinicopathologic correlation and judicious use of frozen section can help in minimizing errors.

UR - http://www.scopus.com/inward/record.url?scp=85019715247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019715247&partnerID=8YFLogxK

U2 - 10.7860/JCDR/2017/25341.9941

DO - 10.7860/JCDR/2017/25341.9941

M3 - Article

VL - 11

SP - ER04-ER06

JO - Journal of Clinical and Diagnostic Research

JF - Journal of Clinical and Diagnostic Research

SN - 2249-782X

IS - 5

ER -