Multiparticulate drug delivery system of aceclofenac: Development and in vitro studies

G.V. Shavi, U. Nayak, R.K. Averineni, K. Arumugam, S.R. Meka, U. Nayanabhirama, P. Sureshwar

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20 Citations (Scopus)


The aim of this study was to develop an enteric-coated multiunit dosage form containing aceclofenac, a nonsteroidal anti-inflammatory drug. The pellets were prepared by using extrusion/spheronization method, and the core pellets were coated with a pH-sensitive poly(meth) acrylate copolymer (Eudragit L100-55) to achieve site-specific drug release. The formulated pellets were characterized for percentage yield, size distribution, surface morphology studies, drug content, and flow properties. In vitro dissolution test was used for comparison of drug release profiles of various coated pellets. The practical yield was found to be 90-95%. The particle size of enteric-coated pellets was found to be in the range of 0.59-0.71 mm. The pellets were spherical in shape and surfaces of pellets were found to be rough and showing micropores. Enteric-coated pellets showed good flow properties and in vitro dissolution profile. Dissolution tests were carried out in a USP type II dissolution apparatus in media-simulating pH conditions of the gastrointestinal tract. The release of the aceclofenac from formulated pellets was established to be minimum in the pH 1.2 (
Original languageEnglish
Pages (from-to)252-258
Number of pages7
JournalDrug Development and Industrial Pharmacy
Issue number2
Publication statusPublished - 2009


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