Multiple approaches for achieving drug solubility: an in silico perspective

Torsa Das, Chetan H. Mehta, Usha Y. Nayak

Research output: Contribution to journalArticle

Abstract

Discovering new therapeutically active molecules is the ultimate destination in pharmaceutical research and development. Most drugs discovered are lipophilic and, hence, exhibit poor aqueous solubility, resulting in low bioavailability. Thus, there is a need to use various solubility enhancement techniques. Computational approaches enable the analysis of drug–carrier interactions or the numerous conformational changes in the carrier matrix that might establish an appropriate balance between cohesive and adhesive stability in a formulation. In this review, we discuss research approaches that provided molecular insight into drugs and their modifiers to unravel their solubility, stability, and bioavailability.

Original languageEnglish
JournalDrug Discovery Today
DOIs
Publication statusAccepted/In press - 01-01-2020

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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