Multiple signaling pathways coordinately mediate reactive oxygen species dependent cardiomyocyte hypertrophy

Indira K. Adiga, Renuka R. Nair

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The heart responds to an increased demand arising due to physiological stimuli or pathological insults by hypertrophy of myocytes. Reactive oxygen species (ROS) have recently been identified as the molecular intermediates in the translation of mechanical stimuli to cellular response. Different signal transduction pathways have been implicated with cardiac hypertrophy, prominent among them being, mitogen-activated protein kinase (MAPK), protein kinase C (PKC) and calcineurin. It remains unclear whether the ROS induced hypertrophy is mediated through one or more of these pathways. This study was taken up with the objective to affirm the role of ROS in the induction of cardiomyocyte hypertrophy and examine the contribution of specific pathways in the mediation of the hypertrophic response. The cellular response to enzyme-generated reactive oxygen species was examined in cultured cells from newborn rat heart. Pathway specific inhibitors were used to identify the role of each pathway in the mediation of cellular hypertrophy. Cellular hypertrophy in response to hypoxanthine-xanthine oxidase was prevented by inhibition of any one of the pathways; leading to the inference that oxidative stress induced hypertrophy is mediated by coordinative regulation of the three major pathways.

Original languageEnglish
Pages (from-to)346-351
Number of pages6
JournalCell Biochemistry and Function
Volume26
Issue number3
DOIs
Publication statusPublished - 01-04-2008

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Cardiac Myocytes
Hypertrophy
Reactive Oxygen Species
Signal transduction
Oxidative stress
Xanthine Oxidase
Calcineurin
Mitogen-Activated Protein Kinases
Protein Kinase C
Rats
Mitogen-Activated Protein Kinase Kinases
Cells
Cardiomegaly
Muscle Cells
Cultured Cells
Signal Transduction
Oxidative Stress
Enzymes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology

Cite this

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Multiple signaling pathways coordinately mediate reactive oxygen species dependent cardiomyocyte hypertrophy. / Adiga, Indira K.; Nair, Renuka R.

In: Cell Biochemistry and Function, Vol. 26, No. 3, 01.04.2008, p. 346-351.

Research output: Contribution to journalArticle

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