Multisystem langerhans cell histiocytosis in adult

Anubhav Garg, Pramod Kumar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Langerhans cell histiocytosis (LCH), is a rare disorder, clinically presents with heterogeneous manifestations, and has an unpredictable outcome. Commonly seen in infancy or early childhood, the disorder is characterized by proliferation of abnormal and clonal Langerhans cell in skin, bone, lymph nodes, lungs, liver, spleen, and bone marrow. Occurrence of LCH in adults is rare. Here, we report the case of an adult with acute onset of polymorphic eruptions all over the body, which on biopsy showed features of multisystem LCH, and was confirmed by immunohistochemistry. Although multisystem LCH has a poor prognosis, our patient responded well to chemotherapy.

Original languageEnglish
Pages (from-to)58-60
Number of pages3
JournalIndian Journal of Dermatology
Volume57
Issue number1
DOIs
Publication statusPublished - 01-01-2012

Fingerprint

Langerhans Cell Histiocytosis
Langerhans Cells
Spleen
Lymph Nodes
Bone Marrow
Immunohistochemistry
Biopsy
Bone and Bones
Drug Therapy
Lung
Skin
Liver

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

@article{69c02383d8334f028e4e10e7aa4e1d2b,
title = "Multisystem langerhans cell histiocytosis in adult",
abstract = "Langerhans cell histiocytosis (LCH), is a rare disorder, clinically presents with heterogeneous manifestations, and has an unpredictable outcome. Commonly seen in infancy or early childhood, the disorder is characterized by proliferation of abnormal and clonal Langerhans cell in skin, bone, lymph nodes, lungs, liver, spleen, and bone marrow. Occurrence of LCH in adults is rare. Here, we report the case of an adult with acute onset of polymorphic eruptions all over the body, which on biopsy showed features of multisystem LCH, and was confirmed by immunohistochemistry. Although multisystem LCH has a poor prognosis, our patient responded well to chemotherapy.",
author = "Anubhav Garg and Pramod Kumar",
year = "2012",
month = "1",
day = "1",
doi = "10.4103/0019-5154.92683",
language = "English",
volume = "57",
pages = "58--60",
journal = "Indian Journal of Dermatology",
issn = "0019-5154",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",

}

Multisystem langerhans cell histiocytosis in adult. / Garg, Anubhav; Kumar, Pramod.

In: Indian Journal of Dermatology, Vol. 57, No. 1, 01.01.2012, p. 58-60.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Multisystem langerhans cell histiocytosis in adult

AU - Garg, Anubhav

AU - Kumar, Pramod

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Langerhans cell histiocytosis (LCH), is a rare disorder, clinically presents with heterogeneous manifestations, and has an unpredictable outcome. Commonly seen in infancy or early childhood, the disorder is characterized by proliferation of abnormal and clonal Langerhans cell in skin, bone, lymph nodes, lungs, liver, spleen, and bone marrow. Occurrence of LCH in adults is rare. Here, we report the case of an adult with acute onset of polymorphic eruptions all over the body, which on biopsy showed features of multisystem LCH, and was confirmed by immunohistochemistry. Although multisystem LCH has a poor prognosis, our patient responded well to chemotherapy.

AB - Langerhans cell histiocytosis (LCH), is a rare disorder, clinically presents with heterogeneous manifestations, and has an unpredictable outcome. Commonly seen in infancy or early childhood, the disorder is characterized by proliferation of abnormal and clonal Langerhans cell in skin, bone, lymph nodes, lungs, liver, spleen, and bone marrow. Occurrence of LCH in adults is rare. Here, we report the case of an adult with acute onset of polymorphic eruptions all over the body, which on biopsy showed features of multisystem LCH, and was confirmed by immunohistochemistry. Although multisystem LCH has a poor prognosis, our patient responded well to chemotherapy.

UR - http://www.scopus.com/inward/record.url?scp=84858844095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858844095&partnerID=8YFLogxK

U2 - 10.4103/0019-5154.92683

DO - 10.4103/0019-5154.92683

M3 - Article

VL - 57

SP - 58

EP - 60

JO - Indian Journal of Dermatology

JF - Indian Journal of Dermatology

SN - 0019-5154

IS - 1

ER -