Mutation spectrum of COL1A1 and COL1A2 genes in Indian patients with osteogenesis imperfecta

Joshi Stephen, Anju Shukla, Ashwin Dalal, Katta Mohan Girisha, Hitesh Shah, Neerja Gupta, Madhulika Kabra, Preeti Dabadghao, Shubha R. Phadke

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21 Citations (Scopus)


Osteogenesis imperfecta (OI) is a condition of decreased bone density with heterogeneous etiologies. Most of the cases are inherited in an autosomal dominant fashion and are caused by mutations in the COL1A1 or COL1A2 genes. Since these two genes are very large, there are no data about mutations in Indian patients with OI. We selected 35 Indian patients who were clinically diagnosed with OI and all exons of both the genes were sequenced. Mutations in COL1A1 (14 cases, 6 novel) and COL1A2 (11 cases, 7 novel) were identified in 25 patients. A total of 55 polymorphisms were identified in both the genes with eight novel variants in the coding region, and nine novel variants in the non-coding regions. No mutation was detected in 10 patients. Six of them were from consanguineous families, with one or two similarly affected siblings suggesting possible autosomal recessive inheritance. If we exclude families with consanguinity, mutations were identified in 25 out of 29 families giving 86% mutation detection rate. Mutations in COL1A1 accounted for 56% of the cases and COL1A2 44%, which is similar to the reported rate worldwide.

Original languageEnglish
Pages (from-to)1482-1489
Number of pages8
JournalAmerican Journal of Medical Genetics, Part A
Issue number6
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)


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