N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: An intermediate in the synthesis of valsartan

Hemmige S. Yathirajan; Basavegowda Nagaraj; Santhosh L. Gaonkar; Rajenahally S. Narasegowda; Padmarajaiah Nagaraja; Basappa Prabhuswamy; Michael Bolte

doi:10.1107/S1600536804026790

N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: An intermediate in the synthesis of valsartan

Hemmige S. Yathirajan, Basavegowda Nagaraj, Santhosh L. Gaonkar, Rajenahally S. Narasegowda, Padmarajaiah Nagaraja, Basappa Prabhuswamy, Michael Bolte

Department of Chemistry, Manipal Institute of Technology, Manipal

Research output: Contribution to journal › Article › peer-review

Abstract

The title compound {systematic name: methyl 2-[(2′-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride), C₂₀H₂₃N₂O²⁺·Cl^-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.

Original language	English
Journal	Acta Crystallographica Section E: Structure Reports Online
Volume	60
Issue number	11
DOIs	https://doi.org/10.1107/S1600536804026790
Publication status	Published - 11-2004

All Science Journal Classification (ASJC) codes

Chemistry(all)
Materials Science(all)
Condensed Matter Physics

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Yathirajan, Hemmige S. ; Nagaraj, Basavegowda ; Gaonkar, Santhosh L. ; Narasegowda, Rajenahally S. ; Nagaraja, Padmarajaiah ; Prabhuswamy, Basappa ; Bolte, Michael. / N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride : An intermediate in the synthesis of valsartan. In: Acta Crystallographica Section E: Structure Reports Online. 2004 ; Vol. 60, No. 11.

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title = "N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: An intermediate in the synthesis of valsartan",

abstract = "The title compound {systematic name: methyl 2-[(2′-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride), C20H23N2O2+·Cl-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.",

author = "Yathirajan, {Hemmige S.} and Basavegowda Nagaraj and Gaonkar, {Santhosh L.} and Narasegowda, {Rajenahally S.} and Padmarajaiah Nagaraja and Basappa Prabhuswamy and Michael Bolte",

year = "2004",

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doi = "10.1107/S1600536804026790",

language = "English",

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journal = "Acta Crystallographica Section E: Structure Reports Online",

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N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride : An intermediate in the synthesis of valsartan. / Yathirajan, Hemmige S.; Nagaraj, Basavegowda; Gaonkar, Santhosh L.; Narasegowda, Rajenahally S.; Nagaraja, Padmarajaiah; Prabhuswamy, Basappa; Bolte, Michael.

In: Acta Crystallographica Section E: Structure Reports Online, Vol. 60, No. 11, 11.2004.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride

T2 - An intermediate in the synthesis of valsartan

AU - Yathirajan, Hemmige S.

AU - Nagaraj, Basavegowda

AU - Gaonkar, Santhosh L.

AU - Narasegowda, Rajenahally S.

AU - Nagaraja, Padmarajaiah

AU - Prabhuswamy, Basappa

AU - Bolte, Michael

PY - 2004/11

Y1 - 2004/11

N2 - The title compound {systematic name: methyl 2-[(2′-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride), C20H23N2O2+·Cl-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.

AB - The title compound {systematic name: methyl 2-[(2′-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride), C20H23N2O2+·Cl-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.

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JO - Acta Crystallographica Section E: Structure Reports Online

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SN - 1600-5368

IS - 11

ER -

N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: An intermediate in the synthesis of valsartan

Abstract

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