N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: An intermediate in the synthesis of valsartan

Hemmige S. Yathirajan, Basavegowda Nagaraj, Santhosh L. Gaonkar, Rajenahally S. Narasegowda, Padmarajaiah Nagaraja, Basappa Prabhuswamy, Michael Bolte

Research output: Contribution to journalArticle

Abstract

The title compound {systematic name: methyl 2-[(2′-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride), C20H23N2O2+·Cl-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.

Original languageEnglish
JournalActa Crystallographica Section E: Structure Reports Online
Volume60
Issue number11
DOIs
Publication statusPublished - 11-2004

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Valsartan
Valine
hydrochlorides
Cations
Chlorides
esters
Esters
Positive ions
chlorides
Ions
cations
synthesis
ions
valine methyl ester

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Yathirajan, Hemmige S. ; Nagaraj, Basavegowda ; Gaonkar, Santhosh L. ; Narasegowda, Rajenahally S. ; Nagaraja, Padmarajaiah ; Prabhuswamy, Basappa ; Bolte, Michael. / N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride : An intermediate in the synthesis of valsartan. In: Acta Crystallographica Section E: Structure Reports Online. 2004 ; Vol. 60, No. 11.
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N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride : An intermediate in the synthesis of valsartan. / Yathirajan, Hemmige S.; Nagaraj, Basavegowda; Gaonkar, Santhosh L.; Narasegowda, Rajenahally S.; Nagaraja, Padmarajaiah; Prabhuswamy, Basappa; Bolte, Michael.

In: Acta Crystallographica Section E: Structure Reports Online, Vol. 60, No. 11, 11.2004.

Research output: Contribution to journalArticle

TY - JOUR

T1 - N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride

T2 - An intermediate in the synthesis of valsartan

AU - Yathirajan, Hemmige S.

AU - Nagaraj, Basavegowda

AU - Gaonkar, Santhosh L.

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AU - Nagaraja, Padmarajaiah

AU - Prabhuswamy, Basappa

AU - Bolte, Michael

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