N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: An intermediate in the synthesis of valsartan

Hemmige S. Yathirajan, Basavegowda Nagaraj, Santhosh L. Gaonkar, Rajenahally S. Narasegowda, Padmarajaiah Nagaraja, Basappa Prabhuswamy, Michael Bolte

Research output: Contribution to journalArticle


The title compound {systematic name: methyl 2-[(2′-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride), C20H23N2O2+·Cl-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.

Original languageEnglish
JournalActa Crystallographica Section E: Structure Reports Online
Issue number11
Publication statusPublished - 11-2004


All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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