N-acetylcysteine reverses late gestational stress induced maternal oxidative damage

Liegelin Kavitha Bernhardt, K. Lakshminarayana Bairy, Sampath Madhyastha

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: This study was intended to investigate the effect of early and late gestational stress, on the levels of antioxidants and antioxidant enzymes in maternal serum that reflects oxidative damage. We also aimed at evaluating the protective role of N-acetylcysteine (NAC) against this oxidative stress. This study was carried out with speculation in mind that maternal oxidative damage could be the cause for developmental defects in off spring. Methods: Pregnant rats were exposed to restrain stress thrice daily, either during the first half or during the second half of gestation. Other groups were treated with N-acetylcysteine throughout pregnancy, along with exposure to either early gestational stress or late gestational stress. Control group was kept undisturbed throughout pregnancy. Immediately after delivery, blood was drawn to estimate the serum antioxidant levels. Results: Pregnant rats exposed to stress during the late gestational period showed significant variation in the level of serum MDA, Glutathione Reductase, reduced glutathione, SOD and total antioxidant capacity although, administration of NAC brought about improvement in the antioxidant status. Conclusion: NAC is an effective antioxidant that can bring down the oxidative damage caused by late gestational stress in rats.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume7
Issue number1
Publication statusPublished - 01-01-2015
Externally publishedYes

Fingerprint

Acetylcysteine
Antioxidants
Mothers
monodehydroascorbate reductase (NADH)
Pregnancy
Serum
Glutathione Reductase
Glutathione
Oxidative Stress
Control Groups
Enzymes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Bernhardt, Liegelin Kavitha ; Lakshminarayana Bairy, K. ; Madhyastha, Sampath. / N-acetylcysteine reverses late gestational stress induced maternal oxidative damage. In: International Journal of Pharmacy and Pharmaceutical Sciences. 2015 ; Vol. 7, No. 1. pp. 165-168.
@article{82f8d114b02d4ec5a9d3f649958bf1ef,
title = "N-acetylcysteine reverses late gestational stress induced maternal oxidative damage",
abstract = "Objective: This study was intended to investigate the effect of early and late gestational stress, on the levels of antioxidants and antioxidant enzymes in maternal serum that reflects oxidative damage. We also aimed at evaluating the protective role of N-acetylcysteine (NAC) against this oxidative stress. This study was carried out with speculation in mind that maternal oxidative damage could be the cause for developmental defects in off spring. Methods: Pregnant rats were exposed to restrain stress thrice daily, either during the first half or during the second half of gestation. Other groups were treated with N-acetylcysteine throughout pregnancy, along with exposure to either early gestational stress or late gestational stress. Control group was kept undisturbed throughout pregnancy. Immediately after delivery, blood was drawn to estimate the serum antioxidant levels. Results: Pregnant rats exposed to stress during the late gestational period showed significant variation in the level of serum MDA, Glutathione Reductase, reduced glutathione, SOD and total antioxidant capacity although, administration of NAC brought about improvement in the antioxidant status. Conclusion: NAC is an effective antioxidant that can bring down the oxidative damage caused by late gestational stress in rats.",
author = "Bernhardt, {Liegelin Kavitha} and {Lakshminarayana Bairy}, K. and Sampath Madhyastha",
year = "2015",
month = "1",
day = "1",
language = "English",
volume = "7",
pages = "165--168",
journal = "International Journal of Pharmacy and Pharmaceutical Sciences",
issn = "0975-1491",
publisher = "IJPPS",
number = "1",

}

N-acetylcysteine reverses late gestational stress induced maternal oxidative damage. / Bernhardt, Liegelin Kavitha; Lakshminarayana Bairy, K.; Madhyastha, Sampath.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, No. 1, 01.01.2015, p. 165-168.

Research output: Contribution to journalArticle

TY - JOUR

T1 - N-acetylcysteine reverses late gestational stress induced maternal oxidative damage

AU - Bernhardt, Liegelin Kavitha

AU - Lakshminarayana Bairy, K.

AU - Madhyastha, Sampath

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective: This study was intended to investigate the effect of early and late gestational stress, on the levels of antioxidants and antioxidant enzymes in maternal serum that reflects oxidative damage. We also aimed at evaluating the protective role of N-acetylcysteine (NAC) against this oxidative stress. This study was carried out with speculation in mind that maternal oxidative damage could be the cause for developmental defects in off spring. Methods: Pregnant rats were exposed to restrain stress thrice daily, either during the first half or during the second half of gestation. Other groups were treated with N-acetylcysteine throughout pregnancy, along with exposure to either early gestational stress or late gestational stress. Control group was kept undisturbed throughout pregnancy. Immediately after delivery, blood was drawn to estimate the serum antioxidant levels. Results: Pregnant rats exposed to stress during the late gestational period showed significant variation in the level of serum MDA, Glutathione Reductase, reduced glutathione, SOD and total antioxidant capacity although, administration of NAC brought about improvement in the antioxidant status. Conclusion: NAC is an effective antioxidant that can bring down the oxidative damage caused by late gestational stress in rats.

AB - Objective: This study was intended to investigate the effect of early and late gestational stress, on the levels of antioxidants and antioxidant enzymes in maternal serum that reflects oxidative damage. We also aimed at evaluating the protective role of N-acetylcysteine (NAC) against this oxidative stress. This study was carried out with speculation in mind that maternal oxidative damage could be the cause for developmental defects in off spring. Methods: Pregnant rats were exposed to restrain stress thrice daily, either during the first half or during the second half of gestation. Other groups were treated with N-acetylcysteine throughout pregnancy, along with exposure to either early gestational stress or late gestational stress. Control group was kept undisturbed throughout pregnancy. Immediately after delivery, blood was drawn to estimate the serum antioxidant levels. Results: Pregnant rats exposed to stress during the late gestational period showed significant variation in the level of serum MDA, Glutathione Reductase, reduced glutathione, SOD and total antioxidant capacity although, administration of NAC brought about improvement in the antioxidant status. Conclusion: NAC is an effective antioxidant that can bring down the oxidative damage caused by late gestational stress in rats.

UR - http://www.scopus.com/inward/record.url?scp=84937557156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937557156&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84937557156

VL - 7

SP - 165

EP - 168

JO - International Journal of Pharmacy and Pharmaceutical Sciences

JF - International Journal of Pharmacy and Pharmaceutical Sciences

SN - 0975-1491

IS - 1

ER -