N-Acetylcysteine versus arsenic poisoning: A mechanistic study of complexation by molecular spectroscopy and density functional theory

Moumita Das, Keshav Kumar Singh, Eram Khan, Rajeev K. Sinha, Ranjan K. Singh, Poonam Tandon, Debraj Gangopadhyay

Research output: Contribution to journalArticlepeer-review

Abstract

Arsenic poisoning is a critical health hazard. Here we investigate the mechanism that enables N-Acetylcysteine (NAC), an antioxidant drug, to act as an antitoxin of arsenic poisoning. Concentration dependent Raman spectral analysis determined the precise molar ratio (3:1) at which a water-soluble complex between NAC and arsenic is formed. Stability and geometry of the complex was inferred by characterizing the synthesized complex using Raman and surface enhanced Raman spectroscopic (SERS) techniques. Density functional theory (DFT) based studies were performed to understand the nature of interaction between NAC and arsenic at molecular level, as well as to elucidate the structural changes taking place during complexation. The combined experimental and theoretical study suggests that a stable complex between NAC and arsenic is formed in three steps. This study highlights the high affinity of NAC towards arsenic and may help to identify the way NAC is expected to protect biomolecules from the toxic effect of arsenic.

Original languageEnglish
Article number117168
JournalJournal of Molecular Liquids
Volume340
DOIs
Publication statusPublished - 15-10-2021

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'N-Acetylcysteine versus arsenic poisoning: A mechanistic study of complexation by molecular spectroscopy and density functional theory'. Together they form a unique fingerprint.

Cite this