N-substituted phenothiazine derivatives as potent antimicrobials

Synthesis and structural characterization

N. N. Madhushree, K. Shiva Prasad, Sudhir Nayak, P. G. Chandrashekar

Research output: Contribution to journalArticle

Abstract

A series of N-substituted phenothiazine derived chloro compounds (3a-3c) and morpholine based compounds (5a-5c) were synthesized by base catalyzed reactions. The molecular structures of synthesized compounds were confirmed by using various spectral techniques viz., FT-IR, 1H, 13C NMR and mass spectroscopy. The strong stretching vibrational bands in the region 1696-1670 cm-1in FT-IR spectral analysis confirms the presence of carbonyl moiety in the synthesized compounds. The presence of signals in the downfield region of proton NMR of 5a-5c is due to methylene protons which confirms their formation. The antimicrobial investigations was carried out against two gram positive bacterial species such as Bacillus subtilis and Staphylococcusaureus. The antifungal activity was tested against AspergillusflavusandAspergillusniger. The biological results obtained suggests that the microbial growth inhibition was much higher in the chloro based N-phenothiazine derivatives (3a-3c) than its morpholine derivative (5a-5c).

Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalDer Pharma Chemica
Volume8
Issue number1
Publication statusPublished - 01-01-2016
Externally publishedYes

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Protons
Nuclear magnetic resonance
Derivatives
Bacilli
Spectrum analysis
Molecular structure
Stretching
Spectroscopy
phenothiazine
morpholine

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Madhushree, N. N., Shiva Prasad, K., Nayak, S., & Chandrashekar, P. G. (2016). N-substituted phenothiazine derivatives as potent antimicrobials: Synthesis and structural characterization. Der Pharma Chemica, 8(1), 351-357.
Madhushree, N. N. ; Shiva Prasad, K. ; Nayak, Sudhir ; Chandrashekar, P. G. / N-substituted phenothiazine derivatives as potent antimicrobials : Synthesis and structural characterization. In: Der Pharma Chemica. 2016 ; Vol. 8, No. 1. pp. 351-357.
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Madhushree, NN, Shiva Prasad, K, Nayak, S & Chandrashekar, PG 2016, 'N-substituted phenothiazine derivatives as potent antimicrobials: Synthesis and structural characterization', Der Pharma Chemica, vol. 8, no. 1, pp. 351-357.

N-substituted phenothiazine derivatives as potent antimicrobials : Synthesis and structural characterization. / Madhushree, N. N.; Shiva Prasad, K.; Nayak, Sudhir; Chandrashekar, P. G.

In: Der Pharma Chemica, Vol. 8, No. 1, 01.01.2016, p. 351-357.

Research output: Contribution to journalArticle

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Madhushree NN, Shiva Prasad K, Nayak S, Chandrashekar PG. N-substituted phenothiazine derivatives as potent antimicrobials: Synthesis and structural characterization. Der Pharma Chemica. 2016 Jan 1;8(1):351-357.