Nanocrystals: A newer technological advancement in drug delivery

Neha Xalxo, Anup Naha, Abhishek Dhoot, Juhi Priya

Research output: Contribution to journalReview article

Abstract

Solubility is defined as dissolution of a solute in a solvent to give a homogenous system. It is an important consideration which is required to achieve appropriate drug concentration in systemic circulation for a chosen pharmacological response. With innovation in technologies, the discoveries of drugs having better efficacy are restricted due to poor solubility, despite having clinical efficacy. Hence it has become a major challenge. More than 50% new chemical entities produced in pharmacy industry are practically insoluble in water. Nano crystals have potential to overcome this issue. They have size in nanometer range (mean diameter < 1000nm) which changes the drug properties dramatically. This review article summaries different methods of preparation, various production technologies available currently in industries; evaluation techniques, applications of nano crystal formulation, future trends and challenges of nano crystal formulation, and various marketed dosage forms developed using nano crystals are discussed.

Original languageEnglish
Pages (from-to)1685-1690
Number of pages6
JournalResearch Journal of Pharmacy and Technology
Volume11
Issue number4
DOIs
Publication statusPublished - 01-04-2018

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All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)

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