Nanometals in Dentistry: Applications and Toxicological Implications—a Systematic Review

Rupali Agnihotri, Sumit Gaur, Sacharia Albin

Research output: Contribution to journalReview article

Abstract

Nanotechnology is a vital part of health care system, including the dentistry. This branch of technology has been incorporated into various fields of dentistry ranging from diagnosis to prevention and treatment. The latter involves application of numerous biomaterials that help in restoration of esthetic and functional dentition. Over the past decade, these materials were modified through the incorporation of metal nanoparticles (NP) like silver (Ag), gold (Au), titanium (Ti), zinc (Zn), copper (Cu), and zirconia (Zr). They enhanced antimicrobial, mechanical, and regenerative properties of these materials. However, lately, the toxicological implications of these nanometal particles have been realized. They were associated with cytotoxicity, genotoxicity altered inflammatory processes, and reticuloendothelial system toxicity. As dental biomaterials containing metal NPs remain functional in oral cavity over prolonged periods, it is important to know their toxicological effects in humans. With this background, the present systematic review is aimed to gain an insight into the plausible applications and toxic implications of nano-metal particles as related to dentistry.

Original languageEnglish
JournalBiological Trace Element Research
DOIs
Publication statusAccepted/In press - 01-01-2019

Fingerprint

Dentistry
Toxicology
Biocompatible Materials
Metals
Metal Nanoparticles
Mononuclear Phagocyte System
Nanotechnology
Dentition
Metal nanoparticles
Poisons
Cytotoxicity
Titanium
Esthetics
Health care
Silver
Gold
Restoration
Toxicity
Mouth
Zinc

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

Cite this

@article{237f1097f7ef4030801e6c75ab997fa0,
title = "Nanometals in Dentistry: Applications and Toxicological Implications—a Systematic Review",
abstract = "Nanotechnology is a vital part of health care system, including the dentistry. This branch of technology has been incorporated into various fields of dentistry ranging from diagnosis to prevention and treatment. The latter involves application of numerous biomaterials that help in restoration of esthetic and functional dentition. Over the past decade, these materials were modified through the incorporation of metal nanoparticles (NP) like silver (Ag), gold (Au), titanium (Ti), zinc (Zn), copper (Cu), and zirconia (Zr). They enhanced antimicrobial, mechanical, and regenerative properties of these materials. However, lately, the toxicological implications of these nanometal particles have been realized. They were associated with cytotoxicity, genotoxicity altered inflammatory processes, and reticuloendothelial system toxicity. As dental biomaterials containing metal NPs remain functional in oral cavity over prolonged periods, it is important to know their toxicological effects in humans. With this background, the present systematic review is aimed to gain an insight into the plausible applications and toxic implications of nano-metal particles as related to dentistry.",
author = "Rupali Agnihotri and Sumit Gaur and Sacharia Albin",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s12011-019-01986-y",
language = "English",
journal = "Biological Trace Element Research",
issn = "0163-4984",
publisher = "Humana Press",

}

TY - JOUR

T1 - Nanometals in Dentistry

T2 - Applications and Toxicological Implications—a Systematic Review

AU - Agnihotri, Rupali

AU - Gaur, Sumit

AU - Albin, Sacharia

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Nanotechnology is a vital part of health care system, including the dentistry. This branch of technology has been incorporated into various fields of dentistry ranging from diagnosis to prevention and treatment. The latter involves application of numerous biomaterials that help in restoration of esthetic and functional dentition. Over the past decade, these materials were modified through the incorporation of metal nanoparticles (NP) like silver (Ag), gold (Au), titanium (Ti), zinc (Zn), copper (Cu), and zirconia (Zr). They enhanced antimicrobial, mechanical, and regenerative properties of these materials. However, lately, the toxicological implications of these nanometal particles have been realized. They were associated with cytotoxicity, genotoxicity altered inflammatory processes, and reticuloendothelial system toxicity. As dental biomaterials containing metal NPs remain functional in oral cavity over prolonged periods, it is important to know their toxicological effects in humans. With this background, the present systematic review is aimed to gain an insight into the plausible applications and toxic implications of nano-metal particles as related to dentistry.

AB - Nanotechnology is a vital part of health care system, including the dentistry. This branch of technology has been incorporated into various fields of dentistry ranging from diagnosis to prevention and treatment. The latter involves application of numerous biomaterials that help in restoration of esthetic and functional dentition. Over the past decade, these materials were modified through the incorporation of metal nanoparticles (NP) like silver (Ag), gold (Au), titanium (Ti), zinc (Zn), copper (Cu), and zirconia (Zr). They enhanced antimicrobial, mechanical, and regenerative properties of these materials. However, lately, the toxicological implications of these nanometal particles have been realized. They were associated with cytotoxicity, genotoxicity altered inflammatory processes, and reticuloendothelial system toxicity. As dental biomaterials containing metal NPs remain functional in oral cavity over prolonged periods, it is important to know their toxicological effects in humans. With this background, the present systematic review is aimed to gain an insight into the plausible applications and toxic implications of nano-metal particles as related to dentistry.

UR - http://www.scopus.com/inward/record.url?scp=85075896452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075896452&partnerID=8YFLogxK

U2 - 10.1007/s12011-019-01986-y

DO - 10.1007/s12011-019-01986-y

M3 - Review article

C2 - 31782063

AN - SCOPUS:85075896452

JO - Biological Trace Element Research

JF - Biological Trace Element Research

SN - 0163-4984

ER -