Naringin and naringenin inhibit nitrite-induced methemoglobin formation

M.S. Kumar, M.K. Unnikrishnan, S. Patra, K. Murthy, K.K. Srinivasan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Naringin and naringenin protect hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when naringin and naringenin are added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of naringin and naringenin to scavenge oxygen free radicals may be responsible for the action because superoxide, hydroxyl and other free radicals are implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite. Both compounds showed less ability to protect intact erythrocytes suggesting that they may not cross the erythrocyte membrane in sufficient amounts. Naringenin was more effective than naringin, probably because of the extra phenolic group in the aglycone.
Original languageEnglish
Pages (from-to)564-566
Number of pages3
JournalPharmazie
Volume58
Issue number8
Publication statusPublished - 2003

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Methemoglobin
Nitrites
Hemoglobins
Free Radicals
Erythrocyte Membrane
Superoxides
Hydroxyl Radical
Reactive Oxygen Species
Erythrocytes
naringin
naringenin

Cite this

Kumar, M. S., Unnikrishnan, M. K., Patra, S., Murthy, K., & Srinivasan, K. K. (2003). Naringin and naringenin inhibit nitrite-induced methemoglobin formation. Pharmazie, 58(8), 564-566.
Kumar, M.S. ; Unnikrishnan, M.K. ; Patra, S. ; Murthy, K. ; Srinivasan, K.K. / Naringin and naringenin inhibit nitrite-induced methemoglobin formation. In: Pharmazie. 2003 ; Vol. 58, No. 8. pp. 564-566.
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abstract = "Naringin and naringenin protect hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when naringin and naringenin are added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of naringin and naringenin to scavenge oxygen free radicals may be responsible for the action because superoxide, hydroxyl and other free radicals are implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite. Both compounds showed less ability to protect intact erythrocytes suggesting that they may not cross the erythrocyte membrane in sufficient amounts. Naringenin was more effective than naringin, probably because of the extra phenolic group in the aglycone.",
author = "M.S. Kumar and M.K. Unnikrishnan and S. Patra and K. Murthy and K.K. Srinivasan",
note = "Cited By :23 Export Date: 10 November 2017 CODEN: PHARA Correspondence Address: Kumar, M.S.; Department of Pharmacology, College of Pharmaceutical Sciences, Manipal - 576119, India; email: cheruvaloor@yahoo.com Chemicals/CAS: aurantiin, 10236-47-2, 12619-61-3, 29658-83-1, 82350-96-7; curcumin, 458-37-7; naringenin, 480-41-1, 67604-48-2; nitrite, 14797-65-0; superoxide, 11062-77-4; Antioxidants; Flavanones; Flavonoids; Free Radical Scavengers; Methemoglobin, 9008-37-1; naringenin, 480-41-1; naringin, 10236-47-2; Nitrites References: Hilmy, A.M., El-Domiaty, N.A., Weshana, K., (1987) Biochem. Physiol. C., 86, p. 247; Bath, R.N., Eddy, F.B., (1980) J. Exp. Zool., 214, p. 119; Doyle, M.P., Pickering, R.A., Dykstra, R.L., Nelson, C.L., Boyer, R.E., (1982) Biochem. Biophy. Res. Commun., 105, p. 127; Smith, R.C., Nunn, V., (1984) Arch. Biochem. Biophys., 232, p. 348; Halliwell, B., Hu, M.L., Louie, S., Duvall, T.R., Tarkington, B.K., Motchnik, P., Cross, C.E., (1992) FEBS Letters, 313, p. 62; Ho, P.C., Saville, D.J., Coville, P.F., Wanwimolruk, S., (2000) Pharm. Acta. Helv., 74, p. 379; Chen, Y.T., Zheng, R.L., Jia, Z.J., Ju, Y., (1990) Free Radic. Biol. Med., 9, p. 19; Reena, G.P., Gopinadhan, P., (2001) Food Biotech., 15, p. 179; Ratty, A.K., Das, N.P., (1988) Biochem. Med. Metab. Biol., 39, p. 69; Unnikrishnan, M.K., Rao, M.N.A., (1992) FEBS Letters, 301, p. 195",
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Kumar, MS, Unnikrishnan, MK, Patra, S, Murthy, K & Srinivasan, KK 2003, 'Naringin and naringenin inhibit nitrite-induced methemoglobin formation', Pharmazie, vol. 58, no. 8, pp. 564-566.

Naringin and naringenin inhibit nitrite-induced methemoglobin formation. / Kumar, M.S.; Unnikrishnan, M.K.; Patra, S.; Murthy, K.; Srinivasan, K.K.

In: Pharmazie, Vol. 58, No. 8, 2003, p. 564-566.

Research output: Contribution to journalArticle

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T1 - Naringin and naringenin inhibit nitrite-induced methemoglobin formation

AU - Kumar, M.S.

AU - Unnikrishnan, M.K.

AU - Patra, S.

AU - Murthy, K.

AU - Srinivasan, K.K.

N1 - Cited By :23 Export Date: 10 November 2017 CODEN: PHARA Correspondence Address: Kumar, M.S.; Department of Pharmacology, College of Pharmaceutical Sciences, Manipal - 576119, India; email: cheruvaloor@yahoo.com Chemicals/CAS: aurantiin, 10236-47-2, 12619-61-3, 29658-83-1, 82350-96-7; curcumin, 458-37-7; naringenin, 480-41-1, 67604-48-2; nitrite, 14797-65-0; superoxide, 11062-77-4; Antioxidants; Flavanones; Flavonoids; Free Radical Scavengers; Methemoglobin, 9008-37-1; naringenin, 480-41-1; naringin, 10236-47-2; Nitrites References: Hilmy, A.M., El-Domiaty, N.A., Weshana, K., (1987) Biochem. Physiol. C., 86, p. 247; Bath, R.N., Eddy, F.B., (1980) J. Exp. Zool., 214, p. 119; Doyle, M.P., Pickering, R.A., Dykstra, R.L., Nelson, C.L., Boyer, R.E., (1982) Biochem. Biophy. Res. Commun., 105, p. 127; Smith, R.C., Nunn, V., (1984) Arch. Biochem. Biophys., 232, p. 348; Halliwell, B., Hu, M.L., Louie, S., Duvall, T.R., Tarkington, B.K., Motchnik, P., Cross, C.E., (1992) FEBS Letters, 313, p. 62; Ho, P.C., Saville, D.J., Coville, P.F., Wanwimolruk, S., (2000) Pharm. Acta. Helv., 74, p. 379; Chen, Y.T., Zheng, R.L., Jia, Z.J., Ju, Y., (1990) Free Radic. Biol. Med., 9, p. 19; Reena, G.P., Gopinadhan, P., (2001) Food Biotech., 15, p. 179; Ratty, A.K., Das, N.P., (1988) Biochem. Med. Metab. Biol., 39, p. 69; Unnikrishnan, M.K., Rao, M.N.A., (1992) FEBS Letters, 301, p. 195

PY - 2003

Y1 - 2003

N2 - Naringin and naringenin protect hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when naringin and naringenin are added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of naringin and naringenin to scavenge oxygen free radicals may be responsible for the action because superoxide, hydroxyl and other free radicals are implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite. Both compounds showed less ability to protect intact erythrocytes suggesting that they may not cross the erythrocyte membrane in sufficient amounts. Naringenin was more effective than naringin, probably because of the extra phenolic group in the aglycone.

AB - Naringin and naringenin protect hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when naringin and naringenin are added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of naringin and naringenin to scavenge oxygen free radicals may be responsible for the action because superoxide, hydroxyl and other free radicals are implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite. Both compounds showed less ability to protect intact erythrocytes suggesting that they may not cross the erythrocyte membrane in sufficient amounts. Naringenin was more effective than naringin, probably because of the extra phenolic group in the aglycone.

M3 - Article

VL - 58

SP - 564

EP - 566

JO - Die Pharmazie

JF - Die Pharmazie

SN - 0031-7144

IS - 8

ER -

Kumar MS, Unnikrishnan MK, Patra S, Murthy K, Srinivasan KK. Naringin and naringenin inhibit nitrite-induced methemoglobin formation. Pharmazie. 2003;58(8):564-566.