Naturally occurring anti-Kpa in an infant with recurrent bacterial infection: A case report and review of the literature

Dhivya Kandasamy, Shamee Shastry, Deepika Chenna, Ponniah Amutha Prethika, Ashwinkumar Vaidya, Vinu Rajendran

Research output: Contribution to journalArticlepeer-review

Abstract

Naturally occurring anti-Kpa antibody is extremely rare and was first reported in 1957, named after the first producer ‘Penney’. However, the subsequent anti-Kpa reports presented were all anti-Kpa due to isoimmunization. Individuals with severe bacterial infections particularly Gram-negative bacteria are known to be capable of producing cross-reactive antibodies against Kell blood group system. However, such uncommon antibodies like anti-Kpa can be easily missed in routine pre-transfusion testing unless the panel cells containing low incidence antigen are used for antibody screening. Here, we report a case of naturally occurring anti-Kpa antibody, identified incidentally during pre-transfusion testing of a 12-month-old female infant with the diagnosis of Niemann–Pick disease and recurrent bacterial (Escherichia coli) infection.

Original languageEnglish
JournalVox Sanguinis
DOIs
Publication statusAccepted/In press - 2021

All Science Journal Classification (ASJC) codes

  • Hematology

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