Nephroprotective effect of aqueous extract of pimpinella anisum in gentamicin induced nephrotoxicity in wistar rats

Nair Aiswarya, Rao R. Rashmi, Shenoy J. Preethi, Vinod Chandran, S. Teerthanath, Pai B. Sunil, K. B. Rakesh, Nair Aiswarya, Rao R. Rashmi, Shenoy J. Preethi, Vinod Chandran, S. Teerthanath, Pai B. Sunil, K. B. Rakesh

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: Pimpinella anisum known for its various medicinal properties is also a natural antioxidant and a free radical scavenger with no documented evidence as a nephroprotective agent. Objective: To evaluate the nephroprotective activity of aqueous extract of Pimpinella anisum seeds in a rodent model of gentamicin induced nephrotoxicity. Materials and Methods: Wistar albino rats of either sex, weighing 150–200 g was divided into 5 groups; normal saline, gentamicin 80mg/kg, intraperitoneally for 8 days, aqueous extract of Pimpinella anisum seeds at 1, 2, and 4g/kg, per oral for 8 days, the test extract administered 3 days prior and concurrently with gentamicin for 5 days. Blood urea, serum creatinine, uric acid and blood urea nitrogen analyses and microscopic examination of kidney were performed. Results: Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in serum urea, serum uric acid, serum creatinine and blood urea nitrogen (107.5±16.92mg/dl, 0.8±0.09 mg/dl, 3.05±0.29 mg/dl, 47.8±9.07 mg/dl) respectively when compared to the saline treated groups. Co-administration of Pimpinella anisum extract with gentamicin decreased the rise in these parameters in a dose dependent manner. Histopathological analysis revealed epithelial loss with intense granular degeneration in gentamicin treated rats, whereas aqueous extract of Pimpinella anisum mitigated the severity of gentamicin-induced renal damage. Conclusion: To conclude, our data suggest that aqueous extract of Pimpinella anisum exhibits reno-protective effect in gentamicin induced renal damage and further studies on its mechanism of action are warranted.

Original languageEnglish
Pages (from-to)403-407
Number of pages5
JournalPharmacognosy Journal
Volume10
Issue number3
DOIs
Publication statusPublished - 01-05-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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