Nerve abscess in Hansen’s disease as part of immune reconstitution inflammatory syndrome

a case report

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Immune reconstitution inflammatory syndrome is an inflammatory reaction in HIV-infected patients after initiation of antiretroviral therapy resulting from restored immunity to specific infectious or non-infectious antigens. A 36-year-old male patient on highly active antiretroviral therapy of six months duration, presented with reddish, tender lesions over medial aspect of arm and a single, anaesthetic patch. Tender fluctuant swellings were seen on the medial aspect of left forearm. A few of them had ruptured spontaneously discharging pus. A skin biopsy from the anaesthetic patch showed caseating epitheloid granulomas. A diagnosis of Hansen’s disease borderline tuberculoid in type 1 reversal reaction, with formation of nerve abscess due to Immune Reconstitution Inflammatory Syndrome was made. The patient was started on multibacillary multidrug therapy as per WHO guidelines and highly active antiretroviral therapy was continued.

Original languageEnglish
Pages (from-to)196-198
Number of pages3
JournalInternational Journal of STD and AIDS
Volume28
Issue number2
DOIs
Publication statusPublished - 01-01-2017

Fingerprint

Immune Reconstitution Inflammatory Syndrome
Leprosy
Abscess
Highly Active Antiretroviral Therapy
Anesthetics
Paucibacillary Leprosy
Suppuration
Granuloma
Forearm
Immunity
Arm
HIV
Guidelines
Biopsy
Antigens
Skin
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

@article{bf5928dba2da4b5989ee1216af3dcee4,
title = "Nerve abscess in Hansen’s disease as part of immune reconstitution inflammatory syndrome: a case report",
abstract = "Immune reconstitution inflammatory syndrome is an inflammatory reaction in HIV-infected patients after initiation of antiretroviral therapy resulting from restored immunity to specific infectious or non-infectious antigens. A 36-year-old male patient on highly active antiretroviral therapy of six months duration, presented with reddish, tender lesions over medial aspect of arm and a single, anaesthetic patch. Tender fluctuant swellings were seen on the medial aspect of left forearm. A few of them had ruptured spontaneously discharging pus. A skin biopsy from the anaesthetic patch showed caseating epitheloid granulomas. A diagnosis of Hansen’s disease borderline tuberculoid in type 1 reversal reaction, with formation of nerve abscess due to Immune Reconstitution Inflammatory Syndrome was made. The patient was started on multibacillary multidrug therapy as per WHO guidelines and highly active antiretroviral therapy was continued.",
author = "Ali, {Neema M.} and Kashinath Nayak and Pramod Kumar",
year = "2017",
month = "1",
day = "1",
doi = "10.1177/0956462416654069",
language = "English",
volume = "28",
pages = "196--198",
journal = "International Journal of STD and AIDS",
issn = "0956-4624",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Nerve abscess in Hansen’s disease as part of immune reconstitution inflammatory syndrome

T2 - a case report

AU - Ali, Neema M.

AU - Nayak, Kashinath

AU - Kumar, Pramod

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Immune reconstitution inflammatory syndrome is an inflammatory reaction in HIV-infected patients after initiation of antiretroviral therapy resulting from restored immunity to specific infectious or non-infectious antigens. A 36-year-old male patient on highly active antiretroviral therapy of six months duration, presented with reddish, tender lesions over medial aspect of arm and a single, anaesthetic patch. Tender fluctuant swellings were seen on the medial aspect of left forearm. A few of them had ruptured spontaneously discharging pus. A skin biopsy from the anaesthetic patch showed caseating epitheloid granulomas. A diagnosis of Hansen’s disease borderline tuberculoid in type 1 reversal reaction, with formation of nerve abscess due to Immune Reconstitution Inflammatory Syndrome was made. The patient was started on multibacillary multidrug therapy as per WHO guidelines and highly active antiretroviral therapy was continued.

AB - Immune reconstitution inflammatory syndrome is an inflammatory reaction in HIV-infected patients after initiation of antiretroviral therapy resulting from restored immunity to specific infectious or non-infectious antigens. A 36-year-old male patient on highly active antiretroviral therapy of six months duration, presented with reddish, tender lesions over medial aspect of arm and a single, anaesthetic patch. Tender fluctuant swellings were seen on the medial aspect of left forearm. A few of them had ruptured spontaneously discharging pus. A skin biopsy from the anaesthetic patch showed caseating epitheloid granulomas. A diagnosis of Hansen’s disease borderline tuberculoid in type 1 reversal reaction, with formation of nerve abscess due to Immune Reconstitution Inflammatory Syndrome was made. The patient was started on multibacillary multidrug therapy as per WHO guidelines and highly active antiretroviral therapy was continued.

UR - http://www.scopus.com/inward/record.url?scp=85011559324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011559324&partnerID=8YFLogxK

U2 - 10.1177/0956462416654069

DO - 10.1177/0956462416654069

M3 - Article

VL - 28

SP - 196

EP - 198

JO - International Journal of STD and AIDS

JF - International Journal of STD and AIDS

SN - 0956-4624

IS - 2

ER -