Neural rim characteristics of healthy South Indians

The Chennai Glaucoma Study

Hemamalini Arvind, Ronnie George, Prema Raju, Ramesh S. Ve, Baskaran Mani, Prashanth Kannan, Lingam Vijaya

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

PURPOSE. To report neural rim dimensions for South Indians and examine rim shape with relevance to clinical evaluation. METHODS. Healthy phakic participants (n = 623) of the Chennai Glaucoma Study with normal frequency-doubling perimetry underwent complete eye examinations including optic disc digital stereophotography. Planimetry was performed under stereoviewing conditions using custom software. Rim area, shape, and associations were examined. Rim area asymmetry was studied in a subgroup of 565 subjects. RESULTS. Mean neuroretinal rim area was 2.29 ± 0.39 mm2. Disc area (P < 0.001) and type of cupping (P < 0.001) were associated with rim area. Mean rim area asymmetry was 0.18 ± 0.15 mm2; 95% of subjects had asymmetry < 0.5 mm2. Disc area asymmetry (0.359, P < 0.0001) and intraocular pressure (IOP) asymmetry (P = 0.004) were related to rim area asymmetry. On average, the inferior rim was thickest and the temporal was thinnest. Mean inferior by superior rim width was 1.18 ± 0.17; 2.5 percentile, 0.9. Thirty-eight (7.1%) subjects had the superior rim thicker than the inferior rim, the occurrence of which was associated with disc torsion (P = 0.002) and male sex (P = 0.04). Of the clinically relevant rim width measures in glaucoma (i.e., inferior, superior, and temporal) the temporal rim was thinnest in 469 (87.8%) eyes. Horizontally oval disc shape (P < 0.0001), type of cupping (P = 0.006), and astigmatism (P = 0.001) were associated with the presence of thicker temporal than superior/inferior rims. CONCLUSIONS. The report provides hitherto unreported neural rim measurements among healthy South Indians. The ISNT rule (inferior rim thicker than superior rim, thicker than nasal rim, thicker than temporal rim) was violated in a significant minority. Physiological associations with such violations are described.

Original languageEnglish
Pages (from-to)3457-3464
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume49
Issue number8
DOIs
Publication statusPublished - 01-08-2008

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Glaucoma
Visual Field Tests
Astigmatism
Optic Disk
Intraocular Pressure
Nose
Healthy Volunteers
Software

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Arvind, Hemamalini ; George, Ronnie ; Raju, Prema ; Ve, Ramesh S. ; Mani, Baskaran ; Kannan, Prashanth ; Vijaya, Lingam. / Neural rim characteristics of healthy South Indians : The Chennai Glaucoma Study. In: Investigative Ophthalmology and Visual Science. 2008 ; Vol. 49, No. 8. pp. 3457-3464.
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abstract = "PURPOSE. To report neural rim dimensions for South Indians and examine rim shape with relevance to clinical evaluation. METHODS. Healthy phakic participants (n = 623) of the Chennai Glaucoma Study with normal frequency-doubling perimetry underwent complete eye examinations including optic disc digital stereophotography. Planimetry was performed under stereoviewing conditions using custom software. Rim area, shape, and associations were examined. Rim area asymmetry was studied in a subgroup of 565 subjects. RESULTS. Mean neuroretinal rim area was 2.29 ± 0.39 mm2. Disc area (P < 0.001) and type of cupping (P < 0.001) were associated with rim area. Mean rim area asymmetry was 0.18 ± 0.15 mm2; 95{\%} of subjects had asymmetry < 0.5 mm2. Disc area asymmetry (0.359, P < 0.0001) and intraocular pressure (IOP) asymmetry (P = 0.004) were related to rim area asymmetry. On average, the inferior rim was thickest and the temporal was thinnest. Mean inferior by superior rim width was 1.18 ± 0.17; 2.5 percentile, 0.9. Thirty-eight (7.1{\%}) subjects had the superior rim thicker than the inferior rim, the occurrence of which was associated with disc torsion (P = 0.002) and male sex (P = 0.04). Of the clinically relevant rim width measures in glaucoma (i.e., inferior, superior, and temporal) the temporal rim was thinnest in 469 (87.8{\%}) eyes. Horizontally oval disc shape (P < 0.0001), type of cupping (P = 0.006), and astigmatism (P = 0.001) were associated with the presence of thicker temporal than superior/inferior rims. CONCLUSIONS. The report provides hitherto unreported neural rim measurements among healthy South Indians. The ISNT rule (inferior rim thicker than superior rim, thicker than nasal rim, thicker than temporal rim) was violated in a significant minority. Physiological associations with such violations are described.",
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Neural rim characteristics of healthy South Indians : The Chennai Glaucoma Study. / Arvind, Hemamalini; George, Ronnie; Raju, Prema; Ve, Ramesh S.; Mani, Baskaran; Kannan, Prashanth; Vijaya, Lingam.

In: Investigative Ophthalmology and Visual Science, Vol. 49, No. 8, 01.08.2008, p. 3457-3464.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neural rim characteristics of healthy South Indians

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AU - Arvind, Hemamalini

AU - George, Ronnie

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AU - Vijaya, Lingam

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N2 - PURPOSE. To report neural rim dimensions for South Indians and examine rim shape with relevance to clinical evaluation. METHODS. Healthy phakic participants (n = 623) of the Chennai Glaucoma Study with normal frequency-doubling perimetry underwent complete eye examinations including optic disc digital stereophotography. Planimetry was performed under stereoviewing conditions using custom software. Rim area, shape, and associations were examined. Rim area asymmetry was studied in a subgroup of 565 subjects. RESULTS. Mean neuroretinal rim area was 2.29 ± 0.39 mm2. Disc area (P < 0.001) and type of cupping (P < 0.001) were associated with rim area. Mean rim area asymmetry was 0.18 ± 0.15 mm2; 95% of subjects had asymmetry < 0.5 mm2. Disc area asymmetry (0.359, P < 0.0001) and intraocular pressure (IOP) asymmetry (P = 0.004) were related to rim area asymmetry. On average, the inferior rim was thickest and the temporal was thinnest. Mean inferior by superior rim width was 1.18 ± 0.17; 2.5 percentile, 0.9. Thirty-eight (7.1%) subjects had the superior rim thicker than the inferior rim, the occurrence of which was associated with disc torsion (P = 0.002) and male sex (P = 0.04). Of the clinically relevant rim width measures in glaucoma (i.e., inferior, superior, and temporal) the temporal rim was thinnest in 469 (87.8%) eyes. Horizontally oval disc shape (P < 0.0001), type of cupping (P = 0.006), and astigmatism (P = 0.001) were associated with the presence of thicker temporal than superior/inferior rims. CONCLUSIONS. The report provides hitherto unreported neural rim measurements among healthy South Indians. The ISNT rule (inferior rim thicker than superior rim, thicker than nasal rim, thicker than temporal rim) was violated in a significant minority. Physiological associations with such violations are described.

AB - PURPOSE. To report neural rim dimensions for South Indians and examine rim shape with relevance to clinical evaluation. METHODS. Healthy phakic participants (n = 623) of the Chennai Glaucoma Study with normal frequency-doubling perimetry underwent complete eye examinations including optic disc digital stereophotography. Planimetry was performed under stereoviewing conditions using custom software. Rim area, shape, and associations were examined. Rim area asymmetry was studied in a subgroup of 565 subjects. RESULTS. Mean neuroretinal rim area was 2.29 ± 0.39 mm2. Disc area (P < 0.001) and type of cupping (P < 0.001) were associated with rim area. Mean rim area asymmetry was 0.18 ± 0.15 mm2; 95% of subjects had asymmetry < 0.5 mm2. Disc area asymmetry (0.359, P < 0.0001) and intraocular pressure (IOP) asymmetry (P = 0.004) were related to rim area asymmetry. On average, the inferior rim was thickest and the temporal was thinnest. Mean inferior by superior rim width was 1.18 ± 0.17; 2.5 percentile, 0.9. Thirty-eight (7.1%) subjects had the superior rim thicker than the inferior rim, the occurrence of which was associated with disc torsion (P = 0.002) and male sex (P = 0.04). Of the clinically relevant rim width measures in glaucoma (i.e., inferior, superior, and temporal) the temporal rim was thinnest in 469 (87.8%) eyes. Horizontally oval disc shape (P < 0.0001), type of cupping (P = 0.006), and astigmatism (P = 0.001) were associated with the presence of thicker temporal than superior/inferior rims. CONCLUSIONS. The report provides hitherto unreported neural rim measurements among healthy South Indians. The ISNT rule (inferior rim thicker than superior rim, thicker than nasal rim, thicker than temporal rim) was violated in a significant minority. Physiological associations with such violations are described.

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