Neurocysticercosis in clinically suspected and MRI proven cases

Evidence of sub-optimal antibody response

Janak Kishore, Chiranjay Mukhopadhyay, Sunil Pradhan, Archana Ayyagari, Rakesh K. Gupta

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Neurocysticercosis (NCC) has a worldwide distribution mainly in the developing countries like India. The study was done to find the seroprevalence of anti-cysticercus antibodies in clinically suspected and MRI proven cases and to corroborate the serological findings with radiological findings (MRI). A hospital based study among 204 suspected patients during January, 1996 to August, 2001 showed that 77 (32.2%, M:F=2.2:1) had serological evidence of NCC. Of the total 189 sera, tested at 1:100 dilution 68 (35.9%) and of the total 50 CSF, tested at 1:5 dilution 9 (18%) were positive for anti-cysticercus IgG antibodies. In 35 cases where both were tested 13 sera (37.1%), 9 CSF (25.7%) and in 7(20%) both sera and CSF were positive. In CSF from 62 patients with tubercular meningitis (disease control) 2 (3.2%) samples whereas in sera of 60 normal blood donors (normal control) 7 (11.7%) samples had anti-cysticercus IgG antibodies. In 33 MRI-positive cases, anti-cysticercus antibodies were seen in 15 (45.4%) patients. Antibodies were seen in 6 of 14 (42.8%) cases with single cortical cyst, 4 of 11(36.3%) with 2-3 cysts and in 5 of 8(62.5%) with multiple cysts. Alternatively, 18 of 33 (54.5%) MRI positive cases lacked anti-cysticercus antibodies. Six MRI negative cases were found to be seropositive and were treated successfully. Hence, immune response was sub-optimal even in MRI positive cases and conversely, few MRI negative cases were seropositive. Since positive response with MRI or serology depends on the stage of the disease, therefore both tests should be done together to confirm or to rule out NCC.

Original languageEnglish
Pages (from-to)290-294
Number of pages5
JournalIndian Journal of Pathology and Microbiology
Volume47
Issue number2
Publication statusPublished - 01-04-2004

Fingerprint

Cysticercus
Neurocysticercosis
Antibody Formation
Cysts
Anti-Idiotypic Antibodies
Serum
Antibodies
Meningeal Tuberculosis
Seroepidemiologic Studies
Serology
Blood Donors
Developing Countries
India

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Microbiology (medical)

Cite this

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title = "Neurocysticercosis in clinically suspected and MRI proven cases: Evidence of sub-optimal antibody response",
abstract = "Neurocysticercosis (NCC) has a worldwide distribution mainly in the developing countries like India. The study was done to find the seroprevalence of anti-cysticercus antibodies in clinically suspected and MRI proven cases and to corroborate the serological findings with radiological findings (MRI). A hospital based study among 204 suspected patients during January, 1996 to August, 2001 showed that 77 (32.2{\%}, M:F=2.2:1) had serological evidence of NCC. Of the total 189 sera, tested at 1:100 dilution 68 (35.9{\%}) and of the total 50 CSF, tested at 1:5 dilution 9 (18{\%}) were positive for anti-cysticercus IgG antibodies. In 35 cases where both were tested 13 sera (37.1{\%}), 9 CSF (25.7{\%}) and in 7(20{\%}) both sera and CSF were positive. In CSF from 62 patients with tubercular meningitis (disease control) 2 (3.2{\%}) samples whereas in sera of 60 normal blood donors (normal control) 7 (11.7{\%}) samples had anti-cysticercus IgG antibodies. In 33 MRI-positive cases, anti-cysticercus antibodies were seen in 15 (45.4{\%}) patients. Antibodies were seen in 6 of 14 (42.8{\%}) cases with single cortical cyst, 4 of 11(36.3{\%}) with 2-3 cysts and in 5 of 8(62.5{\%}) with multiple cysts. Alternatively, 18 of 33 (54.5{\%}) MRI positive cases lacked anti-cysticercus antibodies. Six MRI negative cases were found to be seropositive and were treated successfully. Hence, immune response was sub-optimal even in MRI positive cases and conversely, few MRI negative cases were seropositive. Since positive response with MRI or serology depends on the stage of the disease, therefore both tests should be done together to confirm or to rule out NCC.",
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Neurocysticercosis in clinically suspected and MRI proven cases : Evidence of sub-optimal antibody response. / Kishore, Janak; Mukhopadhyay, Chiranjay; Pradhan, Sunil; Ayyagari, Archana; Gupta, Rakesh K.

In: Indian Journal of Pathology and Microbiology, Vol. 47, No. 2, 01.04.2004, p. 290-294.

Research output: Contribution to journalArticle

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