Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na+, K +-ATPase activity

Sudhanshu Sekhar Sahu, Sampath Madhyastha, Gayathri M. Rao

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Resveratrol, an active ingredient of red wine extracts, has been shown to exhibit neuroprotective effects in several experimental models. Hence in the present study, the protective effects of resveratrol on cognitive deficits induced by prenatal stress were evaluated in offspring, and the possible involvement of Na+, K+-ATPase in learning deficits were explored. Pregnant rats were subjected to restraint stress during early or late gestational period. Another set of rats received resveratrol during the entire gestational period along with early or late gestational stress. The study parameters included various behavioral tests like open field test and Morris water maze test. At the end of the behavioral tests (on 40th postnatal day), the offspring were sacrificed, and their brain homogenate was subjected to Na +, K+-ATPase estimation. Early and late gestational stress affected spatial learning and memory and prenatal resveratrol has reversed these cognitive deficits. The Na+, K+-ATPase activity in the offspring brain homogenate was reduced in the late gestational stress group; however prenatal resveratrol treatment has not affected this activity. These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced cognitive impairment. Though late gestational stress involves Na +, K+-ATPase activity in rat brain homogenate, this would not be the primary cause in prenatal stress-induced cognitive dysfunction.

Original languageEnglish
Pages (from-to)520-525
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume103
Issue number3
DOIs
Publication statusPublished - 01-01-2013

Fingerprint

Neuroprotective Agents
Adenosine Triphosphatases
Rats
Brain
Wine
resveratrol
sodium-translocating ATPase
Cognitive Dysfunction
Theoretical Models
Learning
Water
Data storage equipment

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

@article{c83b12a3c1dd4f8b904788db759845a3,
title = "Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na+, K +-ATPase activity",
abstract = "Resveratrol, an active ingredient of red wine extracts, has been shown to exhibit neuroprotective effects in several experimental models. Hence in the present study, the protective effects of resveratrol on cognitive deficits induced by prenatal stress were evaluated in offspring, and the possible involvement of Na+, K+-ATPase in learning deficits were explored. Pregnant rats were subjected to restraint stress during early or late gestational period. Another set of rats received resveratrol during the entire gestational period along with early or late gestational stress. The study parameters included various behavioral tests like open field test and Morris water maze test. At the end of the behavioral tests (on 40th postnatal day), the offspring were sacrificed, and their brain homogenate was subjected to Na +, K+-ATPase estimation. Early and late gestational stress affected spatial learning and memory and prenatal resveratrol has reversed these cognitive deficits. The Na+, K+-ATPase activity in the offspring brain homogenate was reduced in the late gestational stress group; however prenatal resveratrol treatment has not affected this activity. These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced cognitive impairment. Though late gestational stress involves Na +, K+-ATPase activity in rat brain homogenate, this would not be the primary cause in prenatal stress-induced cognitive dysfunction.",
author = "Sahu, {Sudhanshu Sekhar} and Sampath Madhyastha and Rao, {Gayathri M.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.pbb.2012.09.012",
language = "English",
volume = "103",
pages = "520--525",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "3",

}

Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na+, K +-ATPase activity. / Sahu, Sudhanshu Sekhar; Madhyastha, Sampath; Rao, Gayathri M.

In: Pharmacology Biochemistry and Behavior, Vol. 103, No. 3, 01.01.2013, p. 520-525.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na+, K +-ATPase activity

AU - Sahu, Sudhanshu Sekhar

AU - Madhyastha, Sampath

AU - Rao, Gayathri M.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Resveratrol, an active ingredient of red wine extracts, has been shown to exhibit neuroprotective effects in several experimental models. Hence in the present study, the protective effects of resveratrol on cognitive deficits induced by prenatal stress were evaluated in offspring, and the possible involvement of Na+, K+-ATPase in learning deficits were explored. Pregnant rats were subjected to restraint stress during early or late gestational period. Another set of rats received resveratrol during the entire gestational period along with early or late gestational stress. The study parameters included various behavioral tests like open field test and Morris water maze test. At the end of the behavioral tests (on 40th postnatal day), the offspring were sacrificed, and their brain homogenate was subjected to Na +, K+-ATPase estimation. Early and late gestational stress affected spatial learning and memory and prenatal resveratrol has reversed these cognitive deficits. The Na+, K+-ATPase activity in the offspring brain homogenate was reduced in the late gestational stress group; however prenatal resveratrol treatment has not affected this activity. These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced cognitive impairment. Though late gestational stress involves Na +, K+-ATPase activity in rat brain homogenate, this would not be the primary cause in prenatal stress-induced cognitive dysfunction.

AB - Resveratrol, an active ingredient of red wine extracts, has been shown to exhibit neuroprotective effects in several experimental models. Hence in the present study, the protective effects of resveratrol on cognitive deficits induced by prenatal stress were evaluated in offspring, and the possible involvement of Na+, K+-ATPase in learning deficits were explored. Pregnant rats were subjected to restraint stress during early or late gestational period. Another set of rats received resveratrol during the entire gestational period along with early or late gestational stress. The study parameters included various behavioral tests like open field test and Morris water maze test. At the end of the behavioral tests (on 40th postnatal day), the offspring were sacrificed, and their brain homogenate was subjected to Na +, K+-ATPase estimation. Early and late gestational stress affected spatial learning and memory and prenatal resveratrol has reversed these cognitive deficits. The Na+, K+-ATPase activity in the offspring brain homogenate was reduced in the late gestational stress group; however prenatal resveratrol treatment has not affected this activity. These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced cognitive impairment. Though late gestational stress involves Na +, K+-ATPase activity in rat brain homogenate, this would not be the primary cause in prenatal stress-induced cognitive dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=84868449308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868449308&partnerID=8YFLogxK

U2 - 10.1016/j.pbb.2012.09.012

DO - 10.1016/j.pbb.2012.09.012

M3 - Article

C2 - 23044472

AN - SCOPUS:84868449308

VL - 103

SP - 520

EP - 525

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 3

ER -