New oxadiazole derivatives

Synthesis and appraisal of their potential as antimicrobial agents

Deboleena Dhara, Dhanya Sunil, Pooja R. Kamath, K. Ananda, S. Shrilakshmi, S. Balaji

Research output: Contribution to journalArticle

Abstract

Introduction: The escalating threat due to dwindling effect of antibiotics and challenge of tackling rising drug-resistant infections has gathered high focus in current medicinal research. Methods: In an attempt to find new molecules that can defeat microbial resistance, two new series of 2-[2-substituted ethenyl]-5-(substituted methoxy)-1,3,4-oxadiazole derivatives were synthesized. Various aromatic hydrazides were allowed to undergo cyclization to substituted oxadiazole-2- amines in the presence of cyanogen bromide and further condensed with different heterocyclic aldehydes to give new oxadiazole derivatives. The synthesized molecules were fully characterized by various spectral techniques and tested for antimicrobial activity. Results: Almost all the newly synthesized compounds especially (5g-5l) displayed remarkable growth inhibition against three bacterial strains: M. smegmatis, S. aureus, E. coli and fungi C. albicans. The antimicrobial activity was further confirmed by MIC assay against the same microorganisms. Oxadiazole 5g displayed promising activity with a MIC value of 0.025 mM for two bacteria and fungi, whereas MIC of this compound for E. coli was 0.1 mM. Other active compounds (5h-5l) also exhibited good MIC ranging between 0.313 to 5.0 mM against the selected microorganisms. Docking simulations were generated to explore the potential binding approaches of ligand 5g at the D-alanine:d-alanine ligase (Ddl) protein of E. coli and S. aureus. Conclusion: Molecule 5g was active even at a lower concentration and could probably act as a prospective lead molecule for targeting the drug resistant microorganisms.

Original languageEnglish
Pages (from-to)21-30
Number of pages10
JournalLetters in Drug Design and Discovery
Volume15
Issue number1
DOIs
Publication statusPublished - 01-01-2018

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Oxadiazoles
Anti-Infective Agents
Alanine
Fungi
Smegma
Escherichia coli
Cyanogen Bromide
Escherichia coli Proteins
Cyclization
Drug Delivery Systems
Ligases
Aldehydes
Amines
Anti-Bacterial Agents
Ligands
Bacteria
Growth
Infection
Research
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Dhara, Deboleena ; Sunil, Dhanya ; Kamath, Pooja R. ; Ananda, K. ; Shrilakshmi, S. ; Balaji, S. / New oxadiazole derivatives : Synthesis and appraisal of their potential as antimicrobial agents. In: Letters in Drug Design and Discovery. 2018 ; Vol. 15, No. 1. pp. 21-30.
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New oxadiazole derivatives : Synthesis and appraisal of their potential as antimicrobial agents. / Dhara, Deboleena; Sunil, Dhanya; Kamath, Pooja R.; Ananda, K.; Shrilakshmi, S.; Balaji, S.

In: Letters in Drug Design and Discovery, Vol. 15, No. 1, 01.01.2018, p. 21-30.

Research output: Contribution to journalArticle

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AU - Sunil, Dhanya

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AU - Shrilakshmi, S.

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