Nimesulide incorporated lipid micropheres

An approach to targeting and controlled release

C. G. Geetha Rao, K. Vijayanarayana, M. G. Manoj Kumar, S. Rashmi Rodrigues, D. Satyanarayana, E. V S Subrahmanyam

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nimesulide, a non-steroidal antiinflammatory drug with very short biological half-life was encapsulated within lipid microspheres by a modified solvent evaporation method with an aim of targeting the drug to the site of inflammation and for controlled release. Physiological lipids such as glyceryl tristearate, cholesterol were used instead of synthetic polymer matrix materials. The prepared lipid microspheres were evaluated with respect to particle size distribution, encapsulation efficiency, in vitro release behaviour and in vivo antiinflammatory activity in rats. Lipid microspheres with a suitable average particle size of 6-7μm could be prepared with this method. The drug was released continuously over 12 days with no burst effect with a maximum release of 74%. The in vivo drug release was investigated in rats, by measuring antiinflammatory activity using cotton pellet granuloma method. A single administration of lipid microspheres showed a better antiinflammatory activity when compared to equivalent multiple administrations of the standard nimesulide solution. The drug concentration was higher in the tissues at the site of inflammation of lipid microspheres treated rats. These results indicated the possibility of drug being released at a controlled rate from lipid microspheres and targeted at the inflamed cells.

Original languageEnglish
Pages (from-to)292-296
Number of pages5
JournalIndian Journal of Pharmaceutical Sciences
Volume67
Issue number3
Publication statusPublished - 2005

Fingerprint

nimesulide
Microspheres
Lipids
Anti-Inflammatory Agents
Particle Size
Pharmaceutical Preparations
Inflammation
Drug Delivery Systems
Granuloma
Half-Life
Polymers
Cholesterol

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Geetha Rao, C. G., Vijayanarayana, K., Manoj Kumar, M. G., Rashmi Rodrigues, S., Satyanarayana, D., & Subrahmanyam, E. V. S. (2005). Nimesulide incorporated lipid micropheres: An approach to targeting and controlled release. Indian Journal of Pharmaceutical Sciences, 67(3), 292-296.
Geetha Rao, C. G. ; Vijayanarayana, K. ; Manoj Kumar, M. G. ; Rashmi Rodrigues, S. ; Satyanarayana, D. ; Subrahmanyam, E. V S. / Nimesulide incorporated lipid micropheres : An approach to targeting and controlled release. In: Indian Journal of Pharmaceutical Sciences. 2005 ; Vol. 67, No. 3. pp. 292-296.
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Geetha Rao, CG, Vijayanarayana, K, Manoj Kumar, MG, Rashmi Rodrigues, S, Satyanarayana, D & Subrahmanyam, EVS 2005, 'Nimesulide incorporated lipid micropheres: An approach to targeting and controlled release', Indian Journal of Pharmaceutical Sciences, vol. 67, no. 3, pp. 292-296.

Nimesulide incorporated lipid micropheres : An approach to targeting and controlled release. / Geetha Rao, C. G.; Vijayanarayana, K.; Manoj Kumar, M. G.; Rashmi Rodrigues, S.; Satyanarayana, D.; Subrahmanyam, E. V S.

In: Indian Journal of Pharmaceutical Sciences, Vol. 67, No. 3, 2005, p. 292-296.

Research output: Contribution to journalArticle

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Geetha Rao CG, Vijayanarayana K, Manoj Kumar MG, Rashmi Rodrigues S, Satyanarayana D, Subrahmanyam EVS. Nimesulide incorporated lipid micropheres: An approach to targeting and controlled release. Indian Journal of Pharmaceutical Sciences. 2005;67(3):292-296.