Niosomal entrapment of hydroxypropyl-β-cylodextrin-methotrexate complex as a drug delivery device

I. P. Sheena, U. V. Singh, K. S. Aithal, N. Udupa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An inclusion complex of methotrexate with hydroxypropyl-β-cylodextrin (HPβCyD) was prepared with a view to increase entrapment efficiency and thereby improve the anticancer activity and stability of the drug. The complex and the plain drug were entrapped in the niosomes using cholesterol, Span 60 and dicetyl phosphate. The niosomal entrapment efficiency was higher (89%) in the case of the drug-complex than with the plain drug (67%). When administered to tumour-bearing BALB/c mice at a dose of 5 mg kg-1, the complex entrapped in the niosomes produced a higher percentage increase in life span. Better stability on storage was also observed with the niosome-entrapped complex. Thus complexation of methotrexate with HPβCyD increases the efficiency of entrapment in nonionic surfactant vesicles and the entrapped complex is stable and has improved anticancer activity.

Original languageEnglish
Pages (from-to)579-582
Number of pages4
JournalPharmaceutical Sciences
Volume3
Issue number12
Publication statusPublished - 1997

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Methotrexate
Liposomes
Equipment and Supplies
Pharmaceutical Preparations
Drug Stability
Surface-Active Agents
Cholesterol
Neoplasms
sorbitan monostearate
dicetylphosphate

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Sheena, I. P. ; Singh, U. V. ; Aithal, K. S. ; Udupa, N. / Niosomal entrapment of hydroxypropyl-β-cylodextrin-methotrexate complex as a drug delivery device. In: Pharmaceutical Sciences. 1997 ; Vol. 3, No. 12. pp. 579-582.
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Niosomal entrapment of hydroxypropyl-β-cylodextrin-methotrexate complex as a drug delivery device. / Sheena, I. P.; Singh, U. V.; Aithal, K. S.; Udupa, N.

In: Pharmaceutical Sciences, Vol. 3, No. 12, 1997, p. 579-582.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Niosomal entrapment of hydroxypropyl-β-cylodextrin-methotrexate complex as a drug delivery device

AU - Sheena, I. P.

AU - Singh, U. V.

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AB - An inclusion complex of methotrexate with hydroxypropyl-β-cylodextrin (HPβCyD) was prepared with a view to increase entrapment efficiency and thereby improve the anticancer activity and stability of the drug. The complex and the plain drug were entrapped in the niosomes using cholesterol, Span 60 and dicetyl phosphate. The niosomal entrapment efficiency was higher (89%) in the case of the drug-complex than with the plain drug (67%). When administered to tumour-bearing BALB/c mice at a dose of 5 mg kg-1, the complex entrapped in the niosomes produced a higher percentage increase in life span. Better stability on storage was also observed with the niosome-entrapped complex. Thus complexation of methotrexate with HPβCyD increases the efficiency of entrapment in nonionic surfactant vesicles and the entrapped complex is stable and has improved anticancer activity.

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