Niosomal Plumbagin with Reduced Toxicity and Improved Anticancer Activity in BALB/C Mice

R. A. Raja Naresh, N. Udupa, P. Uma Devi

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Plumbagin niosomes were prepared using a lipid layer hydration method, and drug entrapment was measured. The acute toxicity studies were conducted following treatment with free and niosomal plumbagin. The antitumour activity of niosomal plumbagin in a solid tumour (sarcoma-180) and Ehrlich ascites model was evaluated. Niosome-encapsulated plumbagin was less toxic than free drug. The antitumour activity of the drug was also better after encapsulation. The better anticancer activity can be justified with the help of LD50 survival studies and study of tumour volume doubling time.

Original languageEnglish
Pages (from-to)1128-1132
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Volume48
Issue number11
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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