Multiamellar vesicles (niosomes) of a series of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan trioleate (Span 85) were formulated to study its influence on drug entrapment efficiency, vesicle size and in vitro drug release. Most efficient entrapment of the drug, primaquine phosphate occurred with Span 60. Mean size of unsonicated niosomes showed a regular increase with increasing HLB from span 85 to span 20. The release rate of drug from vesicles dependent on the surfactant used in the preparation of the vesicles.
|Number of pages||3|
|Publication status||Published - 2004|
Varghese, V., Vitta, P., Bakshi, V., Agarwal, S., & Pandey, S. (2004). Niosomes of primaquine: Effect of sorbitan esters (spans) on the vesicular physical characteristics. Indian Drugs, 41(2), 101-103.