Niosomes of primaquine: Effect of sorbitan esters (spans) on the vesicular physical characteristics

V. Varghese, P. Vitta, V. Bakshi, S. Agarwal, S. Pandey

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Multiamellar vesicles (niosomes) of a series of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan trioleate (Span 85) were formulated to study its influence on drug entrapment efficiency, vesicle size and in vitro drug release. Most efficient entrapment of the drug, primaquine phosphate occurred with Span 60. Mean size of unsonicated niosomes showed a regular increase with increasing HLB from span 85 to span 20. The release rate of drug from vesicles dependent on the surfactant used in the preparation of the vesicles.
Original languageEnglish
Pages (from-to)101-103
Number of pages3
JournalIndian Drugs
Volume41
Issue number2
Publication statusPublished - 2004

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Primaquine
Liposomes
Esters
Surface-Active Agents
Pharmaceutical Preparations
sorbitan trioleate
Drug Liberation
sorbitan monolaurate

Cite this

Varghese, V., Vitta, P., Bakshi, V., Agarwal, S., & Pandey, S. (2004). Niosomes of primaquine: Effect of sorbitan esters (spans) on the vesicular physical characteristics. Indian Drugs, 41(2), 101-103.
Varghese, V. ; Vitta, P. ; Bakshi, V. ; Agarwal, S. ; Pandey, S. / Niosomes of primaquine: Effect of sorbitan esters (spans) on the vesicular physical characteristics. In: Indian Drugs. 2004 ; Vol. 41, No. 2. pp. 101-103.
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abstract = "Multiamellar vesicles (niosomes) of a series of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan trioleate (Span 85) were formulated to study its influence on drug entrapment efficiency, vesicle size and in vitro drug release. Most efficient entrapment of the drug, primaquine phosphate occurred with Span 60. Mean size of unsonicated niosomes showed a regular increase with increasing HLB from span 85 to span 20. The release rate of drug from vesicles dependent on the surfactant used in the preparation of the vesicles.",
author = "V. Varghese and P. Vitta and V. Bakshi and S. Agarwal and S. Pandey",
note = "Cited By :7 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Pandey, S.; Department of Pharmaceutics, College of Pharmaceutical Sciences, MAHE, Manipal-576 119, Karnataka, India; email: pandeysureshwar@yahoo.com References: Baillie, A.J., Florence, A.T., Hume, L., Muirhead, G.T., Rogerson, A., The preparation and properties of niosomes - Non-ionic surfactant vesicles (1985) J. Pharm. Pharmacol., 37, pp. 863-868; Florence, A.T., Non-ionic surfactant vesicles - Preparation and characterization (1993) Liposome Technology, 2, pp. 157-176. , Gregoriadis G. (Ed.): CRC Press, Boca Raton, FL; Baillie, A.J., Coombs, G.H., Dolan, T.F., Laurie, J., Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconate (1986) Journal of Pharmacy and Pharmacology, 38 (7), pp. 502-505; Van Hal, D., Bouwstra, J.A., Junginger, H.E., Preparation and characterization of new dermal dosage-form for antipsoriatic drug dithranol based non-ionic surfactant vesicles (1992) Eur. J. Pharm. Biopharm., 38, pp. 47s; Echegoyen, L.E., Hernandez, J.C., Kaifer, A.E., Gokel, G.W., Aggregation of steroidal lariat ethers: The first example of non-ionic liposomes (niosomes) formed from neutral crown ether compound (1988) J. Chem. Soc. Chem. Commun., 12, pp. 836-837; Hofland, H.E.J., Bouwstra, J.A., Ponec, M., Bodde, H.E., Spies, F., Verhoef, J.C., Junginger, H.E., Interaction of non-ionic surfactant vesicles with cultured keratinocytes and human skin in vitro: A survey of toxicological aspects and ultrastructural changes in stratum corneum (1991) J. Control. Rel., 16, pp. 155-168; Azmin, M.N., Florence, A.T., Handjani Vila, R.M., Stuart, J.F.B., Vanlerberghe, G., Whittaker, J.S., The effect of non-ionic surfactant vesicle (noisome) entrapment on the absorption and distribution of methotrexate in mice (1985) J. Pharm. Pharmacol., 37, pp. 237-242; Yoshiok, T., Florence, A.T., Vesicle (noisome)-in- water-in-oil (v/w/o) emulsions -an in-vitro study (1994) Int. J. Pharm., 108, pp. 117-123; Agrawal, S., D'Souza, R., Udupa, N., Guruprasad, K., Umadevi, P., Niosomal daunorubicin with reduced toxicity and improved anticancer activity in swiss mice bearing fibrosarcoma (2000) Indian Drugs, 38 (1), pp. 21-26; Oommen, E., Shenoy, B.D., Udupa, N., Kamath, R., Uma, D.P., Antitumour efficacy of cyclodextrin-complexed and niosome-encapsulated plumbagin in mice bearing melanoma B16F1 (1999) Pharmacy and Pharmacology Communications, 5 (4), pp. 281-285; De Gier, J., Mandersloot, J.G., Van Deenen, L.L.M., Lipid composition and permeability of liposomes (1968) Biochim. Biophys. Acta, 150, pp. 666-675; Wan, L.S.C., Lee, P.F.S., Studies on surface films of sorbitan-esters at the air/water interface: I (1974) Can. J. Pharm. Sci., 9, pp. 82-85",
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Varghese, V, Vitta, P, Bakshi, V, Agarwal, S & Pandey, S 2004, 'Niosomes of primaquine: Effect of sorbitan esters (spans) on the vesicular physical characteristics', Indian Drugs, vol. 41, no. 2, pp. 101-103.

Niosomes of primaquine: Effect of sorbitan esters (spans) on the vesicular physical characteristics. / Varghese, V.; Vitta, P.; Bakshi, V.; Agarwal, S.; Pandey, S.

In: Indian Drugs, Vol. 41, No. 2, 2004, p. 101-103.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Niosomes of primaquine: Effect of sorbitan esters (spans) on the vesicular physical characteristics

AU - Varghese, V.

AU - Vitta, P.

AU - Bakshi, V.

AU - Agarwal, S.

AU - Pandey, S.

N1 - Cited By :7 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Pandey, S.; Department of Pharmaceutics, College of Pharmaceutical Sciences, MAHE, Manipal-576 119, Karnataka, India; email: pandeysureshwar@yahoo.com References: Baillie, A.J., Florence, A.T., Hume, L., Muirhead, G.T., Rogerson, A., The preparation and properties of niosomes - Non-ionic surfactant vesicles (1985) J. Pharm. Pharmacol., 37, pp. 863-868; Florence, A.T., Non-ionic surfactant vesicles - Preparation and characterization (1993) Liposome Technology, 2, pp. 157-176. , Gregoriadis G. (Ed.): CRC Press, Boca Raton, FL; Baillie, A.J., Coombs, G.H., Dolan, T.F., Laurie, J., Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconate (1986) Journal of Pharmacy and Pharmacology, 38 (7), pp. 502-505; Van Hal, D., Bouwstra, J.A., Junginger, H.E., Preparation and characterization of new dermal dosage-form for antipsoriatic drug dithranol based non-ionic surfactant vesicles (1992) Eur. J. Pharm. Biopharm., 38, pp. 47s; Echegoyen, L.E., Hernandez, J.C., Kaifer, A.E., Gokel, G.W., Aggregation of steroidal lariat ethers: The first example of non-ionic liposomes (niosomes) formed from neutral crown ether compound (1988) J. Chem. Soc. Chem. Commun., 12, pp. 836-837; Hofland, H.E.J., Bouwstra, J.A., Ponec, M., Bodde, H.E., Spies, F., Verhoef, J.C., Junginger, H.E., Interaction of non-ionic surfactant vesicles with cultured keratinocytes and human skin in vitro: A survey of toxicological aspects and ultrastructural changes in stratum corneum (1991) J. Control. Rel., 16, pp. 155-168; Azmin, M.N., Florence, A.T., Handjani Vila, R.M., Stuart, J.F.B., Vanlerberghe, G., Whittaker, J.S., The effect of non-ionic surfactant vesicle (noisome) entrapment on the absorption and distribution of methotrexate in mice (1985) J. Pharm. Pharmacol., 37, pp. 237-242; Yoshiok, T., Florence, A.T., Vesicle (noisome)-in- water-in-oil (v/w/o) emulsions -an in-vitro study (1994) Int. J. Pharm., 108, pp. 117-123; Agrawal, S., D'Souza, R., Udupa, N., Guruprasad, K., Umadevi, P., Niosomal daunorubicin with reduced toxicity and improved anticancer activity in swiss mice bearing fibrosarcoma (2000) Indian Drugs, 38 (1), pp. 21-26; Oommen, E., Shenoy, B.D., Udupa, N., Kamath, R., Uma, D.P., Antitumour efficacy of cyclodextrin-complexed and niosome-encapsulated plumbagin in mice bearing melanoma B16F1 (1999) Pharmacy and Pharmacology Communications, 5 (4), pp. 281-285; De Gier, J., Mandersloot, J.G., Van Deenen, L.L.M., Lipid composition and permeability of liposomes (1968) Biochim. Biophys. Acta, 150, pp. 666-675; Wan, L.S.C., Lee, P.F.S., Studies on surface films of sorbitan-esters at the air/water interface: I (1974) Can. J. Pharm. Sci., 9, pp. 82-85

PY - 2004

Y1 - 2004

N2 - Multiamellar vesicles (niosomes) of a series of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan trioleate (Span 85) were formulated to study its influence on drug entrapment efficiency, vesicle size and in vitro drug release. Most efficient entrapment of the drug, primaquine phosphate occurred with Span 60. Mean size of unsonicated niosomes showed a regular increase with increasing HLB from span 85 to span 20. The release rate of drug from vesicles dependent on the surfactant used in the preparation of the vesicles.

AB - Multiamellar vesicles (niosomes) of a series of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan trioleate (Span 85) were formulated to study its influence on drug entrapment efficiency, vesicle size and in vitro drug release. Most efficient entrapment of the drug, primaquine phosphate occurred with Span 60. Mean size of unsonicated niosomes showed a regular increase with increasing HLB from span 85 to span 20. The release rate of drug from vesicles dependent on the surfactant used in the preparation of the vesicles.

M3 - Article

VL - 41

SP - 101

EP - 103

JO - Indian Drugs

JF - Indian Drugs

SN - 0019-462X

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Varghese V, Vitta P, Bakshi V, Agarwal S, Pandey S. Niosomes of primaquine: Effect of sorbitan esters (spans) on the vesicular physical characteristics. Indian Drugs. 2004;41(2):101-103.