Nitric oxide scavenging by curcuminoids

Sreejayan [Unknown], M.N.A. Rao

Research output: Contribution to journalArticle

787 Citations (Scopus)

Abstract

Because curcumin, a compound with anti-inflammatory and anticancer activity, inhibits induction of nitric oxide synthase in activated macrophages and has been shown to be a potent scavenger of free radicals we have investigated whether it can scavenge nitric oxide directly. Curcumin reduced the amount of nitrite formed by the reaction between oxygen and nitric oxide generated from sodium nitroprusside. Other related compounds, e.g. demethoxycurcumin, bisdemethoxycurcumin and diacetylcurcumin were as active as curcumin, indicating that the methoxy and the phenolic groups are not essential for the scavenging activity. The results indicate curcumin to be a scavenger of nitric oxide. Because this compound is implicated in inflammation and cancer, the therapeutic properties of curcumin against these conditions might be at least partly explained by its free-radical scavenging properties, including those toward nitric oxide.
Original languageUndefined/Unknown
Pages (from-to)105-107
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume49
Issue number1
Publication statusPublished - 1997

Cite this

[Unknown], S., & Rao, M. N. A. (1997). Nitric oxide scavenging by curcuminoids. Journal of Pharmacy and Pharmacology, 49(1), 105-107.
[Unknown], Sreejayan ; Rao, M.N.A. / Nitric oxide scavenging by curcuminoids. In: Journal of Pharmacy and Pharmacology. 1997 ; Vol. 49, No. 1. pp. 105-107.
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[Unknown], S & Rao, MNA 1997, 'Nitric oxide scavenging by curcuminoids', Journal of Pharmacy and Pharmacology, vol. 49, no. 1, pp. 105-107.

Nitric oxide scavenging by curcuminoids. / [Unknown], Sreejayan; Rao, M.N.A.

In: Journal of Pharmacy and Pharmacology, Vol. 49, No. 1, 1997, p. 105-107.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nitric oxide scavenging by curcuminoids

AU - [Unknown], Sreejayan

AU - Rao, M.N.A.

N1 - cited By 695

PY - 1997

Y1 - 1997

N2 - Because curcumin, a compound with anti-inflammatory and anticancer activity, inhibits induction of nitric oxide synthase in activated macrophages and has been shown to be a potent scavenger of free radicals we have investigated whether it can scavenge nitric oxide directly. Curcumin reduced the amount of nitrite formed by the reaction between oxygen and nitric oxide generated from sodium nitroprusside. Other related compounds, e.g. demethoxycurcumin, bisdemethoxycurcumin and diacetylcurcumin were as active as curcumin, indicating that the methoxy and the phenolic groups are not essential for the scavenging activity. The results indicate curcumin to be a scavenger of nitric oxide. Because this compound is implicated in inflammation and cancer, the therapeutic properties of curcumin against these conditions might be at least partly explained by its free-radical scavenging properties, including those toward nitric oxide.

AB - Because curcumin, a compound with anti-inflammatory and anticancer activity, inhibits induction of nitric oxide synthase in activated macrophages and has been shown to be a potent scavenger of free radicals we have investigated whether it can scavenge nitric oxide directly. Curcumin reduced the amount of nitrite formed by the reaction between oxygen and nitric oxide generated from sodium nitroprusside. Other related compounds, e.g. demethoxycurcumin, bisdemethoxycurcumin and diacetylcurcumin were as active as curcumin, indicating that the methoxy and the phenolic groups are not essential for the scavenging activity. The results indicate curcumin to be a scavenger of nitric oxide. Because this compound is implicated in inflammation and cancer, the therapeutic properties of curcumin against these conditions might be at least partly explained by its free-radical scavenging properties, including those toward nitric oxide.

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SP - 105

EP - 107

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

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