NO donors with antithrombotic and vasodilating activities, Part 23: Organic azides

K. Satyanarayana, K. Rehse

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Twenty eight organic azides were synthesized and tested for their antithrombotic and blood pressure towering activities in rats (60 mg/kg, p.o.). In fifteen compounds significant antithrombotic effects were observed. In thirteen cases a significant lowering of the blood pressure of spontaneously hypertensive rats (SHR) was seen. The peak activities in both systems were found for hexyl azide (4), 2-phenylethyl azide (14), and 4- pyridinecarboxylic acid azide (23). In these compounds the inhibition of thrombus formation in meserteric arterioles was >20%. The lowering of blood pressure was > 10% and long lasting (> 6 h) in 4 and 14 while 23 had a shorter duration of action (~ 4 h). In two classes of azides, namely branched aliphatic azides (e.g. 2-azidopentane 9) and aliphatic carbonyl derivatives (e.g. benzoyl-azido-methane 17), only antithrombotic properties were observed. A lack of endothelial metabolism is suggested to be the reason for this therapeutically favorable behaviour.
Original languageUndefined/Unknown
Pages (from-to)207-210
Number of pages4
JournalArchiv der Pharmazie
Volume331
Issue number6
DOIs
Publication statusPublished - 1998

Cite this

Satyanarayana, K. ; Rehse, K. / NO donors with antithrombotic and vasodilating activities, Part 23: Organic azides. In: Archiv der Pharmazie. 1998 ; Vol. 331, No. 6. pp. 207-210.
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NO donors with antithrombotic and vasodilating activities, Part 23: Organic azides. / Satyanarayana, K.; Rehse, K.

In: Archiv der Pharmazie, Vol. 331, No. 6, 1998, p. 207-210.

Research output: Contribution to journalArticle

TY - JOUR

T1 - NO donors with antithrombotic and vasodilating activities, Part 23: Organic azides

AU - Satyanarayana, K.

AU - Rehse, K.

N1 - cited By 4

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