Non-invasive in vivo screening of oral malignancy using laser-induced fluorescence based system

Research output: Contribution to journalArticle

Abstract

About 4000 spectra from oral cavity sites have been recorded in vivo from 380 volunteers, under normal (n=133), potentially malignant (n=155), and malignant (n=92) conditions, by excitation with 325 nm CW He-Cd laser. The analyses of the spectra show that the overall spectra arise from about 7–8 bands from different molecular species. In healthy condition (from subjects with no abnormal oral conditions, including tobacco use), buccal mucosa, lip underside, and tongue bottom give spectra very similar to each other, while tongue top, tongue lateral, and palate give spectra different from these as well as from each other. Under potentially malignant and malignant conditions all sites give spectra which are noticeably different for different sites and under different conditions. It is therefore advisable to use separate reference data sets of normal, potentially malignant, or malignant conditions for different sites for optical diagnostic applications.

Original languageEnglish
Pages (from-to)15-26
Number of pages12
JournalSovremennye Tehnologii v Medicine
Volume10
Issue number1
DOIs
Publication statusPublished - 01-01-2018

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Tobacco
Tongue
Screening
Lasers
Fluorescence
Healthy Volunteers
Neoplasms
Palate
Mouth Mucosa
Tobacco Use
Lip
Mouth
Spectrum Analysis
Mucous Membrane

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Non-invasive in vivo screening of oral malignancy using laser-induced fluorescence based system",
abstract = "About 4000 spectra from oral cavity sites have been recorded in vivo from 380 volunteers, under normal (n=133), potentially malignant (n=155), and malignant (n=92) conditions, by excitation with 325 nm CW He-Cd laser. The analyses of the spectra show that the overall spectra arise from about 7–8 bands from different molecular species. In healthy condition (from subjects with no abnormal oral conditions, including tobacco use), buccal mucosa, lip underside, and tongue bottom give spectra very similar to each other, while tongue top, tongue lateral, and palate give spectra different from these as well as from each other. Under potentially malignant and malignant conditions all sites give spectra which are noticeably different for different sites and under different conditions. It is therefore advisable to use separate reference data sets of normal, potentially malignant, or malignant conditions for different sites for optical diagnostic applications.",
author = "A. Patil and Unnikrishnan, {V. K.} and R. Ongole and Pai, {K. M.} and Kartha, {V. B.} and Santhosh Chidangil",
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AU - Patil, A.

AU - Unnikrishnan, V. K.

AU - Ongole, R.

AU - Pai, K. M.

AU - Kartha, V. B.

AU - Chidangil, Santhosh

PY - 2018/1/1

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N2 - About 4000 spectra from oral cavity sites have been recorded in vivo from 380 volunteers, under normal (n=133), potentially malignant (n=155), and malignant (n=92) conditions, by excitation with 325 nm CW He-Cd laser. The analyses of the spectra show that the overall spectra arise from about 7–8 bands from different molecular species. In healthy condition (from subjects with no abnormal oral conditions, including tobacco use), buccal mucosa, lip underside, and tongue bottom give spectra very similar to each other, while tongue top, tongue lateral, and palate give spectra different from these as well as from each other. Under potentially malignant and malignant conditions all sites give spectra which are noticeably different for different sites and under different conditions. It is therefore advisable to use separate reference data sets of normal, potentially malignant, or malignant conditions for different sites for optical diagnostic applications.

AB - About 4000 spectra from oral cavity sites have been recorded in vivo from 380 volunteers, under normal (n=133), potentially malignant (n=155), and malignant (n=92) conditions, by excitation with 325 nm CW He-Cd laser. The analyses of the spectra show that the overall spectra arise from about 7–8 bands from different molecular species. In healthy condition (from subjects with no abnormal oral conditions, including tobacco use), buccal mucosa, lip underside, and tongue bottom give spectra very similar to each other, while tongue top, tongue lateral, and palate give spectra different from these as well as from each other. Under potentially malignant and malignant conditions all sites give spectra which are noticeably different for different sites and under different conditions. It is therefore advisable to use separate reference data sets of normal, potentially malignant, or malignant conditions for different sites for optical diagnostic applications.

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