Nonfunctional adrenocortical carcinoma with foci of osseous metaplasia in a young girl

Research output: Contribution to journalArticle

Abstract

Nonfunctional adrenocortical carcinoma is an extremely rare malignant tumor in children. Unlike the functional tumor which is detected early due to its hormonal presentation, nonfunctional tumor is detected at a later stage. Here we report a case of a 10 year old girl who presented with abdominal mass and symptoms of short duration. No hypertension and cushingoid features were seen. Serum alpha-fetoprotein, urine vanillyl mandelic acid and homovanillic acid levels were not elevated. CT scan showed multiple pulmonary nodules suggestive of metastatic deposits. With gross and light microscopic findings differential diagnoses of hepatoblastoma, paraganglioma, renal cell carcinoma, adrenal cortical and medullary tumours were made. An array of immunohistochemical markers was done and the final diagnosis given was nonfunctional adrenocortical carcinoma with foci of osseous metaplasia.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalIranian Journal of Pathology
Volume7
Issue number2
Publication statusPublished - 27-03-2012

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Adrenocortical Carcinoma
Metaplasia
Multiple Pulmonary Nodules
Brain Stem Neoplasms
Hepatoblastoma
Paraganglioma
Neoplasms
Homovanillic Acid
alpha-Fetoproteins
Renal Cell Carcinoma
Differential Diagnosis
Urine
Hypertension
Light
Serum

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

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title = "Nonfunctional adrenocortical carcinoma with foci of osseous metaplasia in a young girl",
abstract = "Nonfunctional adrenocortical carcinoma is an extremely rare malignant tumor in children. Unlike the functional tumor which is detected early due to its hormonal presentation, nonfunctional tumor is detected at a later stage. Here we report a case of a 10 year old girl who presented with abdominal mass and symptoms of short duration. No hypertension and cushingoid features were seen. Serum alpha-fetoprotein, urine vanillyl mandelic acid and homovanillic acid levels were not elevated. CT scan showed multiple pulmonary nodules suggestive of metastatic deposits. With gross and light microscopic findings differential diagnoses of hepatoblastoma, paraganglioma, renal cell carcinoma, adrenal cortical and medullary tumours were made. An array of immunohistochemical markers was done and the final diagnosis given was nonfunctional adrenocortical carcinoma with foci of osseous metaplasia.",
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Nonfunctional adrenocortical carcinoma with foci of osseous metaplasia in a young girl. / Srinivas, Srilatha Parampalli; Roy, Alfred; Kumar, Vijay.

In: Iranian Journal of Pathology, Vol. 7, No. 2, 27.03.2012, p. 130-134.

Research output: Contribution to journalArticle

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