Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats

Rekha R. Shenoy, Arun T. Sudheendra, Pawan G. Nayak, Piya Paul, N. Gopalan Kutty, C. Mallikarjuna Rao

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Abstract

Ethno-pharmacological relevance: The seeds of Sesamum indicum Linn. (Pedaliaceae) has been used traditionally for the treatment of wounds in Buldhana district of Maharashtra state. Sesamol is the main anti-oxidative constituent contained mainly in the processed sesame seed oil which has not been explored scientifically for its wound healing activity. Aim of the study: To investigate the influence of sesamol (SM) on wound repair, both in normal and dexamethasone (DM) delayed healing processes in albino rats. Materials and methods: Incision, excision and dead space wounds were inflicted on albino rats (180-220 g) of either sex, under ketamine anaesthesia. Group I served as control, group II received SM 50 mg/kg i.p.; group III was treated with dexamethasone (DM) i.m. (0.17 mg/kg) and SM + DM was given to group IV. The tensile strength, wound contraction, hydroxyproline, lysyl oxidase and total RNA and DNA levels (in granulation tissue) were measured. Results: The tensile strength significantly (p < 0.05) increased with SM at 471.40 ± 14.66 g when compared to control at 300.60 ± 9.16 g in normal and DM suppressed healing. No significant change was observed in duration of wound contraction and lysyl oxidase when compared to control at 2.98 ± 0.10 mg. SM treated rats showed a significant (p < 0.05) rise in hydroxyproline levels at 6.45 ± 0.45 mg when compared to control at 1.75 ± 0.20 mg. Conclusion: These results indicate that sesamol could be a promising drug in normal as well as delayed wound healing processes.

Original languageEnglish
Pages (from-to)608-612
Number of pages5
JournalJournal of Ethnopharmacology
Volume133
Issue number2
DOIs
Publication statusPublished - 27-01-2011

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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