Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents

S. Kini, A.R Bhat

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The 1,3,5-trisubstituted-2-pyrazolines were synthesized by refluxing isoniazid with various substituted diarylchalcones in N,N-dimethylformamide at 120-140°. The physical and spectral data such as M.P., Rf, elemental analysis, IR, NMR and Mass was obtained for the synthesized compounds and the structures were confirmed. The screening of the synthesized compounds for antimicrobial activity was performed against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Aspergillus niger.
Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume70
Issue number1
DOIs
Publication statusPublished - 2008

Fingerprint

Dimethylformamide
Aspergillus niger
Antifungal Agents
Isoniazid
Bacillus subtilis
Pseudomonas aeruginosa
Staphylococcus aureus
Escherichia coli
Anti-Bacterial Agents

Cite this

@article{d98ee7ad982a44a59081d924dce3832c,
title = "Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents",
abstract = "The 1,3,5-trisubstituted-2-pyrazolines were synthesized by refluxing isoniazid with various substituted diarylchalcones in N,N-dimethylformamide at 120-140°. The physical and spectral data such as M.P., Rf, elemental analysis, IR, NMR and Mass was obtained for the synthesized compounds and the structures were confirmed. The screening of the synthesized compounds for antimicrobial activity was performed against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Aspergillus niger.",
author = "S. Kini and A.R Bhat",
note = "Cited By :20 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Kini, S.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: suvarna.gk@manipal.edu References: Fahmy, A.M., Hassa, K.M., Khalaf, A.A., Ahmed, R.A., Synthesis of some new beta-lactams, 4-thiazolidinones and pyrazolines (1987) Indian J Chem, 26, pp. 884-887; Das, N.B., Mittra, A.S., Fungicides derived from 2-pyrazolin-5-ones (1978) Indian J Chem, 16, pp. 638-640; Mittra, A.S., Rao, S., Synthesis and Fungicidal activity of some 2,4-disubstituted thiazoles (1977) Indian J Chem, 15, pp. 1062-1063; Rich, S., Horsfall, J.G., Fungitoxicity of heterocyclic nitrogen compounds (1952) Chem Abst, 46, p. 11543; Shah, M., Patel, P., Korgaokar, S., Parekh, H., Synthesis of pyrazolines, isoxazoles and cynopyridines as potential antimicrobial agents (1996) Indian J Chem, 35, pp. 1282-1284; Husain, M.I., Shukla, S., Synthesis and Biological activity of 4-(3-Aryl-4-oxo-2-thioxothiazolidin-5-ylimino)-3-methyl-1-(N,N-disubstituted amino-methyl)pyrazolin-5-ones (1986) Indian J Chem, 25, pp. 983-986; Rangari, V., Gupta, V.N., Atal, C.K., Synthesis, anti-inflammatory and anti-arthritic activity of newer beta-boswellic acid derivatives (1990) Indian J Pharm Sci, 52, pp. 158-160; Nugent, A.R., Murphy, M., Schlachter, T.S., Dunn, C.J., Smith, R.J., Staite, N.D., Pyrazoline Bisphosphonate esters as novel anti-inflammatory and antiarthritic agents (1993) J Med Chem, 36, pp. 134-138; Dhar, D.N., (1981) The Chemistry of Chalcones and Related Compounds, p. 213. , New York: Wiley Interscience;; Ahmed, M., Singh, B., Sharma, R., Talesara, G.L., Synthesis of 1-(N-Alkoxyphthalimido)-3,5-diaryl-2-pyrazolines (2004) Indian J Heterocycl Chem, 14, pp. 23-25; Collee, J.G., Miles, R.S., Watt, B., Laboratory control of antimicrobial therapy (1996) Mackie and McCartney Practical Medical Microbiology, pp. 151-178. , Collee JG, Fraser AG, Marmion BP, Simmons A, editors, 14th ed. New York: Churchill Livingstone;",
year = "2008",
doi = "10.4103/0250-474X.40344",
language = "English",
volume = "70",
pages = "105--108",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",

}

Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents. / Kini, S.; Bhat, A.R.

In: Indian Journal of Pharmaceutical Sciences, Vol. 70, No. 1, 2008, p. 105-108.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents

AU - Kini, S.

AU - Bhat, A.R

N1 - Cited By :20 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Kini, S.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: suvarna.gk@manipal.edu References: Fahmy, A.M., Hassa, K.M., Khalaf, A.A., Ahmed, R.A., Synthesis of some new beta-lactams, 4-thiazolidinones and pyrazolines (1987) Indian J Chem, 26, pp. 884-887; Das, N.B., Mittra, A.S., Fungicides derived from 2-pyrazolin-5-ones (1978) Indian J Chem, 16, pp. 638-640; Mittra, A.S., Rao, S., Synthesis and Fungicidal activity of some 2,4-disubstituted thiazoles (1977) Indian J Chem, 15, pp. 1062-1063; Rich, S., Horsfall, J.G., Fungitoxicity of heterocyclic nitrogen compounds (1952) Chem Abst, 46, p. 11543; Shah, M., Patel, P., Korgaokar, S., Parekh, H., Synthesis of pyrazolines, isoxazoles and cynopyridines as potential antimicrobial agents (1996) Indian J Chem, 35, pp. 1282-1284; Husain, M.I., Shukla, S., Synthesis and Biological activity of 4-(3-Aryl-4-oxo-2-thioxothiazolidin-5-ylimino)-3-methyl-1-(N,N-disubstituted amino-methyl)pyrazolin-5-ones (1986) Indian J Chem, 25, pp. 983-986; Rangari, V., Gupta, V.N., Atal, C.K., Synthesis, anti-inflammatory and anti-arthritic activity of newer beta-boswellic acid derivatives (1990) Indian J Pharm Sci, 52, pp. 158-160; Nugent, A.R., Murphy, M., Schlachter, T.S., Dunn, C.J., Smith, R.J., Staite, N.D., Pyrazoline Bisphosphonate esters as novel anti-inflammatory and antiarthritic agents (1993) J Med Chem, 36, pp. 134-138; Dhar, D.N., (1981) The Chemistry of Chalcones and Related Compounds, p. 213. , New York: Wiley Interscience;; Ahmed, M., Singh, B., Sharma, R., Talesara, G.L., Synthesis of 1-(N-Alkoxyphthalimido)-3,5-diaryl-2-pyrazolines (2004) Indian J Heterocycl Chem, 14, pp. 23-25; Collee, J.G., Miles, R.S., Watt, B., Laboratory control of antimicrobial therapy (1996) Mackie and McCartney Practical Medical Microbiology, pp. 151-178. , Collee JG, Fraser AG, Marmion BP, Simmons A, editors, 14th ed. New York: Churchill Livingstone;

PY - 2008

Y1 - 2008

N2 - The 1,3,5-trisubstituted-2-pyrazolines were synthesized by refluxing isoniazid with various substituted diarylchalcones in N,N-dimethylformamide at 120-140°. The physical and spectral data such as M.P., Rf, elemental analysis, IR, NMR and Mass was obtained for the synthesized compounds and the structures were confirmed. The screening of the synthesized compounds for antimicrobial activity was performed against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Aspergillus niger.

AB - The 1,3,5-trisubstituted-2-pyrazolines were synthesized by refluxing isoniazid with various substituted diarylchalcones in N,N-dimethylformamide at 120-140°. The physical and spectral data such as M.P., Rf, elemental analysis, IR, NMR and Mass was obtained for the synthesized compounds and the structures were confirmed. The screening of the synthesized compounds for antimicrobial activity was performed against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Aspergillus niger.

U2 - 10.4103/0250-474X.40344

DO - 10.4103/0250-474X.40344

M3 - Article

VL - 70

SP - 105

EP - 108

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 1

ER -