TY - JOUR
T1 - Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents
AU - Kini, S.
AU - Bhat, A.R
N1 - Cited By :20
Export Date: 10 November 2017
CODEN: IJSID
Correspondence Address: Kini, S.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: suvarna.gk@manipal.edu
References: Fahmy, A.M., Hassa, K.M., Khalaf, A.A., Ahmed, R.A., Synthesis of some new beta-lactams, 4-thiazolidinones and pyrazolines (1987) Indian J Chem, 26, pp. 884-887; Das, N.B., Mittra, A.S., Fungicides derived from 2-pyrazolin-5-ones (1978) Indian J Chem, 16, pp. 638-640; Mittra, A.S., Rao, S., Synthesis and Fungicidal activity of some 2,4-disubstituted thiazoles (1977) Indian J Chem, 15, pp. 1062-1063; Rich, S., Horsfall, J.G., Fungitoxicity of heterocyclic nitrogen compounds (1952) Chem Abst, 46, p. 11543; Shah, M., Patel, P., Korgaokar, S., Parekh, H., Synthesis of pyrazolines, isoxazoles and cynopyridines as potential antimicrobial agents (1996) Indian J Chem, 35, pp. 1282-1284; Husain, M.I., Shukla, S., Synthesis and Biological activity of 4-(3-Aryl-4-oxo-2-thioxothiazolidin-5-ylimino)-3-methyl-1-(N,N-disubstituted amino-methyl)pyrazolin-5-ones (1986) Indian J Chem, 25, pp. 983-986; Rangari, V., Gupta, V.N., Atal, C.K., Synthesis, anti-inflammatory and anti-arthritic activity of newer beta-boswellic acid derivatives (1990) Indian J Pharm Sci, 52, pp. 158-160; Nugent, A.R., Murphy, M., Schlachter, T.S., Dunn, C.J., Smith, R.J., Staite, N.D., Pyrazoline Bisphosphonate esters as novel anti-inflammatory and antiarthritic agents (1993) J Med Chem, 36, pp. 134-138; Dhar, D.N., (1981) The Chemistry of Chalcones and Related Compounds, p. 213. , New York: Wiley Interscience;; Ahmed, M., Singh, B., Sharma, R., Talesara, G.L., Synthesis of 1-(N-Alkoxyphthalimido)-3,5-diaryl-2-pyrazolines (2004) Indian J Heterocycl Chem, 14, pp. 23-25; Collee, J.G., Miles, R.S., Watt, B., Laboratory control of antimicrobial therapy (1996) Mackie and McCartney Practical Medical Microbiology, pp. 151-178. , Collee JG, Fraser AG, Marmion BP, Simmons A, editors, 14th ed. New York: Churchill Livingstone;
PY - 2008
Y1 - 2008
N2 - The 1,3,5-trisubstituted-2-pyrazolines were synthesized by refluxing isoniazid with various substituted diarylchalcones in N,N-dimethylformamide at 120-140°. The physical and spectral data such as M.P., Rf, elemental analysis, IR, NMR and Mass was obtained for the synthesized compounds and the structures were confirmed. The screening of the synthesized compounds for antimicrobial activity was performed against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Aspergillus niger.
AB - The 1,3,5-trisubstituted-2-pyrazolines were synthesized by refluxing isoniazid with various substituted diarylchalcones in N,N-dimethylformamide at 120-140°. The physical and spectral data such as M.P., Rf, elemental analysis, IR, NMR and Mass was obtained for the synthesized compounds and the structures were confirmed. The screening of the synthesized compounds for antimicrobial activity was performed against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Aspergillus niger.
U2 - 10.4103/0250-474X.40344
DO - 10.4103/0250-474X.40344
M3 - Article
SN - 0250-474X
VL - 70
SP - 105
EP - 108
JO - Indian Journal of Pharmaceutical Sciences
JF - Indian Journal of Pharmaceutical Sciences
IS - 1
ER -