Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents

U. Sankappa Rai, Arun M. Isloor, Prakash shetty, A. M. Vijesh, Nithin Prabhu, Shrikrishna Isloor, M. Thiageeswaran, Hoong Kun Fun

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

An efficient, microwave irradiated synthesis of novel chromeno[2,3-b]-pyrimidine derivatives was carried out. 2-Amino-3,4-dihydro-2H-chromene-3-carbonitrile was converted into imine using N,N-Dimethylacetaldehyde dimethylacetal to give the core intermediate, which was used for the preparation of chromenopyrimidine library, using acetic acid and different amine in microwave irradiation for 5 min. Structures of newly synthesized compounds were confirmed by spectral studies. Compound 6g was characterized by single crystal X-ray analysis. All the compounds were also screened for their anti-microbial activity. Few of the compounds are found to be potential antimicrobials.

Original languageEnglish
Pages (from-to)2695-2699
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number6
DOIs
Publication statusPublished - 01-06-2010

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Imines
Microwave irradiation
X ray analysis
Microwaves
Anti-Infective Agents
Acetic Acid
Amines
Single crystals
Derivatives
Libraries
X-Rays
chromeno(2,3-b)-pyrimidine
5,7-dimethoxy-2-methyl-2H-benzopyran

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Sankappa Rai, U., Isloor, A. M., shetty, P., Vijesh, A. M., Prabhu, N., Isloor, S., ... Fun, H. K. (2010). Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents. European Journal of Medicinal Chemistry, 45(6), 2695-2699. https://doi.org/10.1016/j.ejmech.2010.02.040
Sankappa Rai, U. ; Isloor, Arun M. ; shetty, Prakash ; Vijesh, A. M. ; Prabhu, Nithin ; Isloor, Shrikrishna ; Thiageeswaran, M. ; Fun, Hoong Kun. / Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents. In: European Journal of Medicinal Chemistry. 2010 ; Vol. 45, No. 6. pp. 2695-2699.
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Sankappa Rai, U, Isloor, AM, shetty, P, Vijesh, AM, Prabhu, N, Isloor, S, Thiageeswaran, M & Fun, HK 2010, 'Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents', European Journal of Medicinal Chemistry, vol. 45, no. 6, pp. 2695-2699. https://doi.org/10.1016/j.ejmech.2010.02.040

Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents. / Sankappa Rai, U.; Isloor, Arun M.; shetty, Prakash; Vijesh, A. M.; Prabhu, Nithin; Isloor, Shrikrishna; Thiageeswaran, M.; Fun, Hoong Kun.

In: European Journal of Medicinal Chemistry, Vol. 45, No. 6, 01.06.2010, p. 2695-2699.

Research output: Contribution to journalArticle

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AU - Isloor, Arun M.

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AU - Prabhu, Nithin

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