Novel schiff's bases of substituted 2-amino benzothiazoles

Design, synthesis and antimicrobial activity

D. Sai Priya, S. G. Kini, V. G. Bhatt, E. Rathi, A. Muralidharan, A. Koteshwara

Research output: Contribution to journalArticle

Abstract

Novel Schiff's bases bearing substituted 2-amino benzothiazole were synthesized by single step process through simple condensation of 2-amino benzothiazole and substituted benzaldehydes and further characterized by FTIR, 1HNMR, and Mass spectrometry data. Antimicrobial activity of compounds was performed by agar diffusion method against a panel of bacterial strains such as S. aureus, B. subtilis (Gram-positive bacteria), E. coli, P. aeruginosa (Gram-negative bacteria) and fungal strains such as C. albicans and A. Niger. Compound S13 and S17 had shown potent antifungal activity against C. albicans and A. Niger respectively among the novel Schiff's base compounds when compared to standard, and S13 compound had only shown moderate antibacterial activity against S. aureus amongst all. Molecular docking study was carried out against C. albicans DHFR (Dihydrofolate Reductase) domain to confirm their activity.

Original languageEnglish
Pages (from-to)18-26
Number of pages9
JournalIndian Drugs
Volume55
Issue number4
Publication statusPublished - 01-04-2018

Fingerprint

Benzothiazoles
5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide
Niger
Schiff Bases
Benzaldehydes
Tetrahydrofolate Dehydrogenase
Gram-Positive Bacteria
Fourier Transform Infrared Spectroscopy
Gram-Negative Bacteria
Agar
Mass Spectrometry
Escherichia coli
benzothiazole

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Sai Priya, D., Kini, S. G., Bhatt, V. G., Rathi, E., Muralidharan, A., & Koteshwara, A. (2018). Novel schiff's bases of substituted 2-amino benzothiazoles: Design, synthesis and antimicrobial activity. Indian Drugs, 55(4), 18-26.
Sai Priya, D. ; Kini, S. G. ; Bhatt, V. G. ; Rathi, E. ; Muralidharan, A. ; Koteshwara, A. / Novel schiff's bases of substituted 2-amino benzothiazoles : Design, synthesis and antimicrobial activity. In: Indian Drugs. 2018 ; Vol. 55, No. 4. pp. 18-26.
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Sai Priya, D, Kini, SG, Bhatt, VG, Rathi, E, Muralidharan, A & Koteshwara, A 2018, 'Novel schiff's bases of substituted 2-amino benzothiazoles: Design, synthesis and antimicrobial activity', Indian Drugs, vol. 55, no. 4, pp. 18-26.

Novel schiff's bases of substituted 2-amino benzothiazoles : Design, synthesis and antimicrobial activity. / Sai Priya, D.; Kini, S. G.; Bhatt, V. G.; Rathi, E.; Muralidharan, A.; Koteshwara, A.

In: Indian Drugs, Vol. 55, No. 4, 01.04.2018, p. 18-26.

Research output: Contribution to journalArticle

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Sai Priya D, Kini SG, Bhatt VG, Rathi E, Muralidharan A, Koteshwara A. Novel schiff's bases of substituted 2-amino benzothiazoles: Design, synthesis and antimicrobial activity. Indian Drugs. 2018 Apr 1;55(4):18-26.