1,2,4-Triazolo[3,4-b]thiazole derivatives 5a-j have been synthesized by novel multi-component reaction of 2,4-dichloro-5-fluorophenacyl bromide (1), thiosemicarbazide (2), and aromatic carboxylic acids (4) using phosphorous oxychloride as the cyclizing agent. This reaction protocol is simple, efficient, and requires shorter reaction times in comparison to the conventional multi-step synthesis. The products were identified to be same by an alternate synthesis. All the compounds were screened for their antimicrobial activity against some of bacterial and fungal strains.
|Number of pages||8|
|Journal||Phosphorus, Sulfur and Silicon and the Related Elements|
|Publication status||Published - 06-2004|
All Science Journal Classification (ASJC) codes
- Organic Chemistry
- Inorganic Chemistry