Numb chin syndrome as a manifestation of metastatic squamous cell carcinoma of esophagus

H. Narendra, Satadru Ray

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Numb chin syndrome (NCS) is a sensory neuropathy presenting with numbness of the chin in the distribution of the mental nerve and the branches of the mandibular division of the trigeminal nerve. Though it can be caused by a benign process, NCS should be regarded as being due to malignancy until proven otherwise. Among the malignancies that cause NCS the most common are breast cancer, prostate cancer, and lymphoreticular malignancy. In squamous cell carcinoma (SCC) of the esophagus, spread to the mandible is a rare and often late event. An often overlooked clinical sign in mandibular metastases is hypoesthesia or paresthesia over the peripheral distribution of the inferior alveolar nerve/mental nerve; this sign has been referred to in the literature as NCS or numb lip syndrome or mental nerve neuropathy. Rarely, this may be the first presentation of a disseminated malignancy. Prognosis is usually poor. The discovery of this symptom should alert the clinician to the possibility of disseminated disease. In this article we report a rare case of metastatic SCC of the esophagus in a 40-year-old male patient who presented with NCS. We also review the mechanism, causes, and evaluation of NCS.

Original languageEnglish
Pages (from-to)49-51
Number of pages3
JournalJournal of Cancer Research and Therapeutics
Volume5
Issue number1
DOIs
Publication statusPublished - 01-01-2009

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Chin
Esophagus
Squamous Cell Carcinoma
Mandibular Nerve
Hypesthesia
Neoplasms
Prostatic Neoplasms
Trigeminal Nerve
Paresthesia
Lip
Mandible
Breast Neoplasms
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

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Numb chin syndrome as a manifestation of metastatic squamous cell carcinoma of esophagus. / Narendra, H.; Ray, Satadru.

In: Journal of Cancer Research and Therapeutics, Vol. 5, No. 1, 01.01.2009, p. 49-51.

Research output: Contribution to journalArticle

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