Obesity as an independent risk factor for the development of microalbuminuria

Malleshappa Pavan, Ravi Ranganath, Anup P. Chaudhari, Meenakshi Shetty

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Obesity is one of the important risk factors for coronary heart disease (CHD), hypertension, diabetes and dyslipidemia. This constellation of risk factors is also associated with end-stage renal disease (ESRD), the prevalence of which has increased despite the availability of interventions to control blood sugar and blood pressure and because albuminuria appears early in the natural history of kidney disease, it's a potential target of primary prevention. Objectives: Obesity is common in adults and likely has a causal role for Kidney disease incidence and progression. The aim of this study was to evaluate the association of obesity defined as per Asia-Pacific guidelines with microalbuminuria which is an early marker of kidney disease in adults. Patients and Methods: Observational study based on 120 obese and 120 healthy individuals between 30-70 years of age. Urine albumin-to-creatinine ratio and body mass index (kg/m2) were measured among healthy and obese individuals at Kasturba Medical College, Mangalore, India. Results: There was a strong association between obesity and microalbuminuria. Microalbuminuria was highly prevalent among obese subjects compared to the controls (OR = 15.33, 95% CI: 5.83 to 40.32, P < 0.001) Conclusions: This study supports a significant association between obesity and the presence of microalbuminuria in adults. Given the increasing prevalence of obesity, this association is particularly alarming. A prospective study of the relationship between obesity and early markers of kidney damage in adults is warranted.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalNephro-Urology Monthly
Volume3
Issue number4
Publication statusPublished - 01-01-2011

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Obesity
Kidney Diseases
Albuminuria
Primary Prevention
Dyslipidemias
Chronic Kidney Failure
Observational Studies
Coronary Disease
Disease Progression
Blood Glucose
India
Albumins
Creatinine
Body Mass Index
Urine
Prospective Studies
Guidelines
Blood Pressure
Hypertension
Kidney

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Pavan, Malleshappa ; Ranganath, Ravi ; Chaudhari, Anup P. ; Shetty, Meenakshi. / Obesity as an independent risk factor for the development of microalbuminuria. In: Nephro-Urology Monthly. 2011 ; Vol. 3, No. 4. pp. 160-163.
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Pavan, M, Ranganath, R, Chaudhari, AP & Shetty, M 2011, 'Obesity as an independent risk factor for the development of microalbuminuria', Nephro-Urology Monthly, vol. 3, no. 4, pp. 160-163.

Obesity as an independent risk factor for the development of microalbuminuria. / Pavan, Malleshappa; Ranganath, Ravi; Chaudhari, Anup P.; Shetty, Meenakshi.

In: Nephro-Urology Monthly, Vol. 3, No. 4, 01.01.2011, p. 160-163.

Research output: Contribution to journalArticle

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T1 - Obesity as an independent risk factor for the development of microalbuminuria

AU - Pavan, Malleshappa

AU - Ranganath, Ravi

AU - Chaudhari, Anup P.

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N2 - Background: Obesity is one of the important risk factors for coronary heart disease (CHD), hypertension, diabetes and dyslipidemia. This constellation of risk factors is also associated with end-stage renal disease (ESRD), the prevalence of which has increased despite the availability of interventions to control blood sugar and blood pressure and because albuminuria appears early in the natural history of kidney disease, it's a potential target of primary prevention. Objectives: Obesity is common in adults and likely has a causal role for Kidney disease incidence and progression. The aim of this study was to evaluate the association of obesity defined as per Asia-Pacific guidelines with microalbuminuria which is an early marker of kidney disease in adults. Patients and Methods: Observational study based on 120 obese and 120 healthy individuals between 30-70 years of age. Urine albumin-to-creatinine ratio and body mass index (kg/m2) were measured among healthy and obese individuals at Kasturba Medical College, Mangalore, India. Results: There was a strong association between obesity and microalbuminuria. Microalbuminuria was highly prevalent among obese subjects compared to the controls (OR = 15.33, 95% CI: 5.83 to 40.32, P < 0.001) Conclusions: This study supports a significant association between obesity and the presence of microalbuminuria in adults. Given the increasing prevalence of obesity, this association is particularly alarming. A prospective study of the relationship between obesity and early markers of kidney damage in adults is warranted.

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