Abstract
Protein profiles of homogenized normal cervical tissue samples from hysterectomy subjects and cancerous cervical tissues from biopsy samples collected from patients with different stages of cervical cancer were recorded using High Performance Liquid Chromatography coupled with Laser Induced Fluorescence (HPLC-LIF). The Protein profiles were subjected to Principle Component Analysis to derive statistically significant parameters. Diagnosis of sample types were carried out by matching three parameters - scores of factors, squared residuals, and Mahalanobis Distance. ROC and Youden's Index curves for calibration standards were used for objective estimation of the optimum threshold for decision making and performance.
| Original language | English |
|---|---|
| Title of host publication | Solid State Physics - Proceedings of the 55th DAE Solid State Physics Symposium 2010 |
| Pages | 226-227 |
| Number of pages | 2 |
| Volume | 1349 |
| Edition | PART A |
| DOIs | |
| Publication status | Published - 12-09-2011 |
| Event | 55th DAE Solid State Physics Symposium 2010 - Manipal, India Duration: 26-12-2010 → 30-12-2010 |
Conference
| Conference | 55th DAE Solid State Physics Symposium 2010 |
|---|---|
| Country | India |
| City | Manipal |
| Period | 26-12-10 → 30-12-10 |
All Science Journal Classification (ASJC) codes
- Physics and Astronomy(all)
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Cite this
Patil, A., Bhat, S., Rai, L., Kartha, V. B., & Chidangil, S. (2011). Objective diagnosis of cervical cancer by tissue protein profile analysis. In Solid State Physics - Proceedings of the 55th DAE Solid State Physics Symposium 2010 (PART A ed., Vol. 1349, pp. 226-227) https://doi.org/10.1063/1.3605818