Objective diagnosis of cervical cancer by tissue protein profile analysis

Ajeetkumar Patil, Sujatha Bhat, Lavanya Rai, V. B. Kartha, Santhosh Chidangil

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Protein profiles of homogenized normal cervical tissue samples from hysterectomy subjects and cancerous cervical tissues from biopsy samples collected from patients with different stages of cervical cancer were recorded using High Performance Liquid Chromatography coupled with Laser Induced Fluorescence (HPLC-LIF). The Protein profiles were subjected to Principle Component Analysis to derive statistically significant parameters. Diagnosis of sample types were carried out by matching three parameters - scores of factors, squared residuals, and Mahalanobis Distance. ROC and Youden's Index curves for calibration standards were used for objective estimation of the optimum threshold for decision making and performance.

Original languageEnglish
Title of host publicationSolid State Physics - Proceedings of the 55th DAE Solid State Physics Symposium 2010
Pages226-227
Number of pages2
Volume1349
EditionPART A
DOIs
Publication statusPublished - 12-09-2011
Event55th DAE Solid State Physics Symposium 2010 - Manipal, India
Duration: 26-12-201030-12-2010

Conference

Conference55th DAE Solid State Physics Symposium 2010
CountryIndia
CityManipal
Period26-12-1030-12-10

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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  • Cite this

    Patil, A., Bhat, S., Rai, L., Kartha, V. B., & Chidangil, S. (2011). Objective diagnosis of cervical cancer by tissue protein profile analysis. In Solid State Physics - Proceedings of the 55th DAE Solid State Physics Symposium 2010 (PART A ed., Vol. 1349, pp. 226-227) https://doi.org/10.1063/1.3605818