Abstract
Protein profiles of homogenized normal cervical tissue samples from hysterectomy subjects and cancerous cervical tissues from biopsy samples collected from patients with different stages of cervical cancer were recorded using High Performance Liquid Chromatography coupled with Laser Induced Fluorescence (HPLC-LIF). The Protein profiles were subjected to Principle Component Analysis to derive statistically significant parameters. Diagnosis of sample types were carried out by matching three parameters - scores of factors, squared residuals, and Mahalanobis Distance. ROC and Youden's Index curves for calibration standards were used for objective estimation of the optimum threshold for decision making and performance.
| Original language | English |
|---|---|
| Title of host publication | Solid State Physics - Proceedings of the 55th DAE Solid State Physics Symposium 2010 |
| Pages | 226-227 |
| Number of pages | 2 |
| Volume | 1349 |
| Edition | PART A |
| DOIs | |
| Publication status | Published - 12-09-2011 |
| Event | 55th DAE Solid State Physics Symposium 2010 - Manipal, India Duration: 26-12-2010 → 30-12-2010 |
Conference
| Conference | 55th DAE Solid State Physics Symposium 2010 |
|---|---|
| Country | India |
| City | Manipal |
| Period | 26-12-10 → 30-12-10 |
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All Science Journal Classification (ASJC) codes
- Physics and Astronomy(all)
Cite this
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Objective diagnosis of cervical cancer by tissue protein profile analysis. / Patil, Ajeetkumar; Bhat, Sujatha; Rai, Lavanya; Kartha, V. B.; Chidangil, Santhosh.
Solid State Physics - Proceedings of the 55th DAE Solid State Physics Symposium 2010. Vol. 1349 PART A. ed. 2011. p. 226-227.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Objective diagnosis of cervical cancer by tissue protein profile analysis
AU - Patil, Ajeetkumar
AU - Bhat, Sujatha
AU - Rai, Lavanya
AU - Kartha, V. B.
AU - Chidangil, Santhosh
PY - 2011/9/12
Y1 - 2011/9/12
N2 - Protein profiles of homogenized normal cervical tissue samples from hysterectomy subjects and cancerous cervical tissues from biopsy samples collected from patients with different stages of cervical cancer were recorded using High Performance Liquid Chromatography coupled with Laser Induced Fluorescence (HPLC-LIF). The Protein profiles were subjected to Principle Component Analysis to derive statistically significant parameters. Diagnosis of sample types were carried out by matching three parameters - scores of factors, squared residuals, and Mahalanobis Distance. ROC and Youden's Index curves for calibration standards were used for objective estimation of the optimum threshold for decision making and performance.
AB - Protein profiles of homogenized normal cervical tissue samples from hysterectomy subjects and cancerous cervical tissues from biopsy samples collected from patients with different stages of cervical cancer were recorded using High Performance Liquid Chromatography coupled with Laser Induced Fluorescence (HPLC-LIF). The Protein profiles were subjected to Principle Component Analysis to derive statistically significant parameters. Diagnosis of sample types were carried out by matching three parameters - scores of factors, squared residuals, and Mahalanobis Distance. ROC and Youden's Index curves for calibration standards were used for objective estimation of the optimum threshold for decision making and performance.
UR - http://www.scopus.com/inward/record.url?scp=80052437344&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052437344&partnerID=8YFLogxK
U2 - 10.1063/1.3605818
DO - 10.1063/1.3605818
M3 - Conference contribution
SN - 9780735409057
VL - 1349
SP - 226
EP - 227
BT - Solid State Physics - Proceedings of the 55th DAE Solid State Physics Symposium 2010
ER -