Ocular manifestations of vitiligo

Evaluation and study of any possible association

Shobha G. Pai, Ankit Gupta, Lakshey Dudeja, Madhurima K. Nayak

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Vitiligo is defined as an idiopathic, autoimmune condition characterized by destruction of the melanocytes. Melanocytes in the eye are present in two layers, the uvea and retinal pigment epithelium. Ocular findings in vitiligo have been studied to a very limited extent. Aim: To study the clinical pattern of ocular manifestations in cases diagnosed with vitiligo and to reveal any demographic or clinical feature that might suggest an association or risk factor for ocular involvement in cases of vitiligo. Material and methods: It was a Prospective case control observational study. 75 cases of vitiligo and 75 controls with similar demography were included. Cases were evaluated for relation of ocular involvement with type and duration of vitiligo, location of lesions and demographic characteristics. Simultaneously ocular manifestations of the control group were tested, for significance of the demographic characteristics and analyzed using chi-square test. Results and Conclusions: Ocular involvement in vitiligo is asymptomatic. In 75 diagnosed cases of vitiligo male to female ratio was 1:1.34 and 11 to 30 years age group had maximum number of cases. Iris hypopigmentation (33.3%) was the most frequent followed by fundus changes(30.6%) and hyper-pigmentation of the anterior chamber angle(20%). In the fundus peripapillary chorioretinal atrophy(18/23 cases) is the most common, diffuse hypopigmentation, background tessellation and temporal crescent being the others. The ocular involvement was found to be more in cases with vitiligo lesions located around the orbital or oral or genital areas. The duration of vitiligo and demographic characteristics are not the risk factors for ocular involvement in vitiligo.

Original languageEnglish
Article number10
JournalOnline Journal of Health and Allied Sciences
Volume14
Issue number4
Publication statusPublished - 01-01-2015

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Eye Manifestations
Vitiligo
Demography
Hypopigmentation
Melanocytes
Uvea
Retinal Pigment Epithelium
Pigmentation
Anterior Chamber
Iris
Chi-Square Distribution

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Pai, Shobha G. ; Gupta, Ankit ; Dudeja, Lakshey ; Nayak, Madhurima K. / Ocular manifestations of vitiligo : Evaluation and study of any possible association. In: Online Journal of Health and Allied Sciences. 2015 ; Vol. 14, No. 4.
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abstract = "Background: Vitiligo is defined as an idiopathic, autoimmune condition characterized by destruction of the melanocytes. Melanocytes in the eye are present in two layers, the uvea and retinal pigment epithelium. Ocular findings in vitiligo have been studied to a very limited extent. Aim: To study the clinical pattern of ocular manifestations in cases diagnosed with vitiligo and to reveal any demographic or clinical feature that might suggest an association or risk factor for ocular involvement in cases of vitiligo. Material and methods: It was a Prospective case control observational study. 75 cases of vitiligo and 75 controls with similar demography were included. Cases were evaluated for relation of ocular involvement with type and duration of vitiligo, location of lesions and demographic characteristics. Simultaneously ocular manifestations of the control group were tested, for significance of the demographic characteristics and analyzed using chi-square test. Results and Conclusions: Ocular involvement in vitiligo is asymptomatic. In 75 diagnosed cases of vitiligo male to female ratio was 1:1.34 and 11 to 30 years age group had maximum number of cases. Iris hypopigmentation (33.3{\%}) was the most frequent followed by fundus changes(30.6{\%}) and hyper-pigmentation of the anterior chamber angle(20{\%}). In the fundus peripapillary chorioretinal atrophy(18/23 cases) is the most common, diffuse hypopigmentation, background tessellation and temporal crescent being the others. The ocular involvement was found to be more in cases with vitiligo lesions located around the orbital or oral or genital areas. The duration of vitiligo and demographic characteristics are not the risk factors for ocular involvement in vitiligo.",
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Ocular manifestations of vitiligo : Evaluation and study of any possible association. / Pai, Shobha G.; Gupta, Ankit; Dudeja, Lakshey; Nayak, Madhurima K.

In: Online Journal of Health and Allied Sciences, Vol. 14, No. 4, 10, 01.01.2015.

Research output: Contribution to journalArticle

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