Ocular surface squamous neoplasia in Xeroderma pigmentosum

Rajesh R. Nayak, Gurudutt M. Kamath, Manjunath M. Kamath, Ajay R. Kamath, Susan D'Souza, Roopashree

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Abstract

Xeroderma pigmentosum (XP) is a rare genetic disorder associated with multiple oculocutaneous and neurological manifestations. It occurs due to deficiency of the enzymes responsible for repairing ultraviolet radiationinduced DNA damage. Persistence of un-repaired DNA results in somatic mutations, leading to neoplasia of the skin and ocular surface. As this condition is rare, only isolated case reports of XP with ocular surface squamous neoplasia (OSSN) are found in literature.

Original languageEnglish
Article number15
JournalOnline Journal of Health and Allied Sciences
Volume12
Issue number3
Publication statusPublished - 01-07-2013

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Nayak, R. R., Kamath, G. M., Kamath, M. M., Kamath, A. R., D'Souza, S., & Roopashree (2013). Ocular surface squamous neoplasia in Xeroderma pigmentosum. Online Journal of Health and Allied Sciences, 12(3), [15].