Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells

Yashin Sreenivasan, Pongali B. Raghavendra, Sunil K. Manna

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Abstract

    Chemotherapeutic agent is characterized by its concentration in tumor cells with minimum side effects. Oleandrin, a polyphenolic cardiac glycoside is known to induce apoptosis in tumor cells. However, no report is available on its efficacy in primary cells. In this report we are providing the evidence that oleandrin induces apoptosis, not necrosis in tumor cells but not in primary cells like peripheral blood mononuclear cells (PBMC) and neutrophils. Oleandrin inhibited NF-κB activation in tumor cells but not in primary cells. It induced cell death in NF-κB-overexpressed tumor cells. Oleandrin induced Fas expression thereby inducing apoptosis in tumor cells but not in primary cells. Dominant negative FADD inhibited oleandrin-induced cell death in tumor cells. Overall, these results suggest that oleandrin mediates apoptosis in tumor cells by inducing Fas but not in primary cells indicating its potential anti-cancer property with no or slight side effect.

    Original languageEnglish
    Pages (from-to)308-322
    Number of pages15
    JournalJournal of Clinical Immunology
    Volume26
    Issue number4
    DOIs
    Publication statusPublished - 07-2006

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Immunology and Allergy

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