Oncocytes in Mucoepidermoid Carcinoma of the Palate

Diagnostic Challenges

Rammohan Kumar, Srikant Natarajan, K. S. Sneha, Nunna Sai Chitra, Karen Boaz, Nidhi Manaktala

Research output: Contribution to journalArticle

Abstract

The origin of a salivary gland tumour is attributed to cells at various levels of differentiation which present histologically as diverse tissues and cellular patterns. Mitochondria-rich, eosinophilic oncocytes are cells commonly encountered in salivary gland neoplasms. We report a case of mucoepidermoid carcinoma (MEC) in the palate of a 43-year-old female that exhibited a prominent oncocytic component. While the parotid and submandibular glands have been reported as predominant sites for oncocytic MEC (OMEC), the palate and minor salivary glands are rare sites for occurrence. Also, most of the reported cases of OMEC have been histologically of low-grade mucoepidermoid carcinoma with large cystic spaces and good prognosis. In this article, we discuss the differential diagnosis and diagnostic workup of an MEC presenting with oncocytes.

Original languageEnglish
Article number5741821
JournalCase Reports in Dentistry
Volume2017
DOIs
Publication statusPublished - 01-01-2017

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Oxyphil Cells
Mucoepidermoid Carcinoma
Palate
Salivary Gland Neoplasms
Minor Salivary Glands
Glandular and Epithelial Neoplasms
Submandibular Gland
Parotid Gland
Mitochondria
Differential Diagnosis

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Kumar, Rammohan ; Natarajan, Srikant ; Sneha, K. S. ; Chitra, Nunna Sai ; Boaz, Karen ; Manaktala, Nidhi. / Oncocytes in Mucoepidermoid Carcinoma of the Palate : Diagnostic Challenges. In: Case Reports in Dentistry. 2017 ; Vol. 2017.
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Oncocytes in Mucoepidermoid Carcinoma of the Palate : Diagnostic Challenges. / Kumar, Rammohan; Natarajan, Srikant; Sneha, K. S.; Chitra, Nunna Sai; Boaz, Karen; Manaktala, Nidhi.

In: Case Reports in Dentistry, Vol. 2017, 5741821, 01.01.2017.

Research output: Contribution to journalArticle

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T1 - Oncocytes in Mucoepidermoid Carcinoma of the Palate

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AU - Natarajan, Srikant

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AB - The origin of a salivary gland tumour is attributed to cells at various levels of differentiation which present histologically as diverse tissues and cellular patterns. Mitochondria-rich, eosinophilic oncocytes are cells commonly encountered in salivary gland neoplasms. We report a case of mucoepidermoid carcinoma (MEC) in the palate of a 43-year-old female that exhibited a prominent oncocytic component. While the parotid and submandibular glands have been reported as predominant sites for oncocytic MEC (OMEC), the palate and minor salivary glands are rare sites for occurrence. Also, most of the reported cases of OMEC have been histologically of low-grade mucoepidermoid carcinoma with large cystic spaces and good prognosis. In this article, we discuss the differential diagnosis and diagnostic workup of an MEC presenting with oncocytes.

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